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Late‐Stage (18)F‐Difluoromethyl Labeling of N‐Heteroaromatics with High Molar Activity for PET Imaging

Despite a growing interest in CHF(2) in medicinal chemistry, there is a lack of efficient methods for the insertion of CHF(18)F into druglike compounds. Herein described is a photoredox flow reaction for (18)F‐difluoromethylation of N‐heteroaromatics that are widely used in medicinal chemistry. Foll...

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Detalles Bibliográficos
Autores principales:	Trump, Laura, Lemos, Agostinho, Lallemand, Bénédicte, Pasau, Patrick, Mercier, Joël, Lemaire, Christian, Luxen, André, Genicot, Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790700/ https://www.ncbi.nlm.nih.gov/pubmed/31323171 http://dx.doi.org/10.1002/anie.201907488

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