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Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790715/ https://www.ncbi.nlm.nih.gov/pubmed/30989733 http://dx.doi.org/10.1002/glia.23620 |
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author | Cullen, Carlie L. Senesi, Matteo Tang, Alexander D. Clutterbuck, Mackenzie T. Auderset, Loic O'Rourke, Megan E. Rodger, Jennifer Young, Kaylene M. |
author_facet | Cullen, Carlie L. Senesi, Matteo Tang, Alexander D. Clutterbuck, Mackenzie T. Auderset, Loic O'Rourke, Megan E. Rodger, Jennifer Young, Kaylene M. |
author_sort | Cullen, Carlie L. |
collection | PubMed |
description | Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI‐rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI‐rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis. |
format | Online Article Text |
id | pubmed-6790715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67907152019-10-21 Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain Cullen, Carlie L. Senesi, Matteo Tang, Alexander D. Clutterbuck, Mackenzie T. Auderset, Loic O'Rourke, Megan E. Rodger, Jennifer Young, Kaylene M. Glia Research Articles Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI‐rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI‐rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis. John Wiley & Sons, Inc. 2019-04-16 2019-08 /pmc/articles/PMC6790715/ /pubmed/30989733 http://dx.doi.org/10.1002/glia.23620 Text en © 2019 The Authors. GLIA published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Cullen, Carlie L. Senesi, Matteo Tang, Alexander D. Clutterbuck, Mackenzie T. Auderset, Loic O'Rourke, Megan E. Rodger, Jennifer Young, Kaylene M. Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
title | Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
title_full | Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
title_fullStr | Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
title_full_unstemmed | Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
title_short | Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
title_sort | low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790715/ https://www.ncbi.nlm.nih.gov/pubmed/30989733 http://dx.doi.org/10.1002/glia.23620 |
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