Cargando…

Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain

Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelin...

Descripción completa

Detalles Bibliográficos
Autores principales: Cullen, Carlie L., Senesi, Matteo, Tang, Alexander D., Clutterbuck, Mackenzie T., Auderset, Loic, O'Rourke, Megan E., Rodger, Jennifer, Young, Kaylene M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790715/
https://www.ncbi.nlm.nih.gov/pubmed/30989733
http://dx.doi.org/10.1002/glia.23620
_version_ 1783458831495331840
author Cullen, Carlie L.
Senesi, Matteo
Tang, Alexander D.
Clutterbuck, Mackenzie T.
Auderset, Loic
O'Rourke, Megan E.
Rodger, Jennifer
Young, Kaylene M.
author_facet Cullen, Carlie L.
Senesi, Matteo
Tang, Alexander D.
Clutterbuck, Mackenzie T.
Auderset, Loic
O'Rourke, Megan E.
Rodger, Jennifer
Young, Kaylene M.
author_sort Cullen, Carlie L.
collection PubMed
description Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI‐rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI‐rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis.
format Online
Article
Text
id pubmed-6790715
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-67907152019-10-21 Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain Cullen, Carlie L. Senesi, Matteo Tang, Alexander D. Clutterbuck, Mackenzie T. Auderset, Loic O'Rourke, Megan E. Rodger, Jennifer Young, Kaylene M. Glia Research Articles Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI‐rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI‐rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis. John Wiley & Sons, Inc. 2019-04-16 2019-08 /pmc/articles/PMC6790715/ /pubmed/30989733 http://dx.doi.org/10.1002/glia.23620 Text en © 2019 The Authors. GLIA published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Cullen, Carlie L.
Senesi, Matteo
Tang, Alexander D.
Clutterbuck, Mackenzie T.
Auderset, Loic
O'Rourke, Megan E.
Rodger, Jennifer
Young, Kaylene M.
Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
title Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
title_full Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
title_fullStr Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
title_full_unstemmed Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
title_short Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
title_sort low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790715/
https://www.ncbi.nlm.nih.gov/pubmed/30989733
http://dx.doi.org/10.1002/glia.23620
work_keys_str_mv AT cullencarliel lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT senesimatteo lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT tangalexanderd lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT clutterbuckmackenziet lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT audersetloic lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT orourkemegane lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT rodgerjennifer lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain
AT youngkaylenem lowintensitytranscranialmagneticstimulationpromotesthesurvivalandmaturationofnewbornoligodendrocytesintheadultmousebrain