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Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease

PURPOSE: To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. METHODS: We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-i...

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Autores principales: Vurture, Gregory, Peyronnet, Benoit, Palma, Jose-Alberto, Sussman, Rachael D., Malacarne, Dominique R., Feigin, Andrew, Palmerola, Ricardo, Rosenblum, Nirit, Frucht, Steven, Kaufmann, Horacio, Nitti, Victor W., Brucker, Benjamin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790817/
https://www.ncbi.nlm.nih.gov/pubmed/31607100
http://dx.doi.org/10.5213/inj.1938086.043
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author Vurture, Gregory
Peyronnet, Benoit
Palma, Jose-Alberto
Sussman, Rachael D.
Malacarne, Dominique R.
Feigin, Andrew
Palmerola, Ricardo
Rosenblum, Nirit
Frucht, Steven
Kaufmann, Horacio
Nitti, Victor W.
Brucker, Benjamin M.
author_facet Vurture, Gregory
Peyronnet, Benoit
Palma, Jose-Alberto
Sussman, Rachael D.
Malacarne, Dominique R.
Feigin, Andrew
Palmerola, Ricardo
Rosenblum, Nirit
Frucht, Steven
Kaufmann, Horacio
Nitti, Victor W.
Brucker, Benjamin M.
author_sort Vurture, Gregory
collection PubMed
description PURPOSE: To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. METHODS: We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only patients who complained of overactive bladder (OAB) symptoms and underwent a video-urodynamic study for these symptoms were included. We excluded patients with neurological disorders other than PD and patients with voiding LUTS but without OAB symptoms. RESULTS: We included 42 patients (29 men, 13 women, 74.5±8.1 years old). Seven patients (16.7%) had a postvoid residual (PVR) bladder volume >100 mL and only one reported incomplete bladder emptying. Detrusor overactivity (DO) was found in all 42 patients (100%) and was terminal in 19 (45.2%) and phasic in 22 patients (52.4%). Eighteen patients had detrusor underactivity (DU) (42.3%). Later age of PD diagnosis was the only parameter associated with DU (P=0.02). Patients with bladder outlet obstruction (BOO) were younger than patients without BOO (70.1 years vs. 76.5 years, P=0.004), had later first sensation of bladder filling (173.5 mL vs. 120.3 mL, P=0.02) and first involuntary detrusor contraction (226.4 mL vs. 130.4 mL, P=0.009). CONCLUSIONS: DO is almost universal in all patients with PD complaining of OAB symptoms (97.1%). However, a significant percentage of patients also had BOO (36.8%), DU (47%), and increased PVR (16.7%) indicating that neurogenic DO may not be the only cause of OAB symptoms in PD patients.
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spelling pubmed-67908172019-10-21 Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease Vurture, Gregory Peyronnet, Benoit Palma, Jose-Alberto Sussman, Rachael D. Malacarne, Dominique R. Feigin, Andrew Palmerola, Ricardo Rosenblum, Nirit Frucht, Steven Kaufmann, Horacio Nitti, Victor W. Brucker, Benjamin M. Int Neurourol J Original Article PURPOSE: To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. METHODS: We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only patients who complained of overactive bladder (OAB) symptoms and underwent a video-urodynamic study for these symptoms were included. We excluded patients with neurological disorders other than PD and patients with voiding LUTS but without OAB symptoms. RESULTS: We included 42 patients (29 men, 13 women, 74.5±8.1 years old). Seven patients (16.7%) had a postvoid residual (PVR) bladder volume >100 mL and only one reported incomplete bladder emptying. Detrusor overactivity (DO) was found in all 42 patients (100%) and was terminal in 19 (45.2%) and phasic in 22 patients (52.4%). Eighteen patients had detrusor underactivity (DU) (42.3%). Later age of PD diagnosis was the only parameter associated with DU (P=0.02). Patients with bladder outlet obstruction (BOO) were younger than patients without BOO (70.1 years vs. 76.5 years, P=0.004), had later first sensation of bladder filling (173.5 mL vs. 120.3 mL, P=0.02) and first involuntary detrusor contraction (226.4 mL vs. 130.4 mL, P=0.009). CONCLUSIONS: DO is almost universal in all patients with PD complaining of OAB symptoms (97.1%). However, a significant percentage of patients also had BOO (36.8%), DU (47%), and increased PVR (16.7%) indicating that neurogenic DO may not be the only cause of OAB symptoms in PD patients. Korean Continence Society 2019-09 2019-09-30 /pmc/articles/PMC6790817/ /pubmed/31607100 http://dx.doi.org/10.5213/inj.1938086.043 Text en Copyright © 2019 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vurture, Gregory
Peyronnet, Benoit
Palma, Jose-Alberto
Sussman, Rachael D.
Malacarne, Dominique R.
Feigin, Andrew
Palmerola, Ricardo
Rosenblum, Nirit
Frucht, Steven
Kaufmann, Horacio
Nitti, Victor W.
Brucker, Benjamin M.
Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
title Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
title_full Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
title_fullStr Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
title_full_unstemmed Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
title_short Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
title_sort urodynamic mechanisms underlying overactive bladder symptoms in patients with parkinson disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790817/
https://www.ncbi.nlm.nih.gov/pubmed/31607100
http://dx.doi.org/10.5213/inj.1938086.043
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