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Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer

PURPOSE: Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival. MATERIALS AND METHODS: Pa...

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Autores principales: Kim, Hyung-Jun, Cho, Jun Yeun, Lee, Yeon Joo, Park, Jong Sun, Cho, Young-Jae, Yoon, Ho Il, Chung, Jin-Haeng, Cho, Sukki, Kim, Kwhanmien, Lee, Kyung Won, Lee, Jae Ho, Lee, Choon-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790827/
https://www.ncbi.nlm.nih.gov/pubmed/30913858
http://dx.doi.org/10.4143/crt.2019.057
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author Kim, Hyung-Jun
Cho, Jun Yeun
Lee, Yeon Joo
Park, Jong Sun
Cho, Young-Jae
Yoon, Ho Il
Chung, Jin-Haeng
Cho, Sukki
Kim, Kwhanmien
Lee, Kyung Won
Lee, Jae Ho
Lee, Choon-Taek
author_facet Kim, Hyung-Jun
Cho, Jun Yeun
Lee, Yeon Joo
Park, Jong Sun
Cho, Young-Jae
Yoon, Ho Il
Chung, Jin-Haeng
Cho, Sukki
Kim, Kwhanmien
Lee, Kyung Won
Lee, Jae Ho
Lee, Choon-Taek
author_sort Kim, Hyung-Jun
collection PubMed
description PURPOSE: Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival. MATERIALS AND METHODS: Patients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura. Clinical, radiographical, and pathological findings were analyzed. RESULTS: Among 404 patients with malignant subsolid nodule, 120 (29.7%) had neither pleural attachment nor indentation, 26 (6.4%) had attachment only, 117 (29.0%) had indentation only, and 141 (34.9%) had both. VPI was observed in nodules of 36 patients (8.9%), but absent in nonsolid nodules and in those without pleural attachment and/or indentation. Compared to subsolid nodules with concurrent pleural attachment and indentation, those with attachment only (odds ratio, 0.12; 95% confidence interval [CI], 0.02 to 0.98) and indentation only (odds ratio, 0.10; 95% CI, 0.03 to 0.31) revealed lower odds of VPI. On subgroup analysis, the size of the solid portion was associated with VPI among those with pleural attachment and indentation (p=0.021). Such high-risk features for VPI were associated with earlier lung cancer recurrence (adjusted hazard ratio, 3.31; 95% CI, 1.58 to 6.91). CONCLUSION: Concurrent pleural attachment and indentation are risk factors for VPI, and the odds increase with larger solid portion in subsolid nodules. Considering the risk of recurrence, early surgical resection could be encouraged in these patients.
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spelling pubmed-67908272019-10-21 Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer Kim, Hyung-Jun Cho, Jun Yeun Lee, Yeon Joo Park, Jong Sun Cho, Young-Jae Yoon, Ho Il Chung, Jin-Haeng Cho, Sukki Kim, Kwhanmien Lee, Kyung Won Lee, Jae Ho Lee, Choon-Taek Cancer Res Treat Original Article PURPOSE: Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival. MATERIALS AND METHODS: Patients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura. Clinical, radiographical, and pathological findings were analyzed. RESULTS: Among 404 patients with malignant subsolid nodule, 120 (29.7%) had neither pleural attachment nor indentation, 26 (6.4%) had attachment only, 117 (29.0%) had indentation only, and 141 (34.9%) had both. VPI was observed in nodules of 36 patients (8.9%), but absent in nonsolid nodules and in those without pleural attachment and/or indentation. Compared to subsolid nodules with concurrent pleural attachment and indentation, those with attachment only (odds ratio, 0.12; 95% confidence interval [CI], 0.02 to 0.98) and indentation only (odds ratio, 0.10; 95% CI, 0.03 to 0.31) revealed lower odds of VPI. On subgroup analysis, the size of the solid portion was associated with VPI among those with pleural attachment and indentation (p=0.021). Such high-risk features for VPI were associated with earlier lung cancer recurrence (adjusted hazard ratio, 3.31; 95% CI, 1.58 to 6.91). CONCLUSION: Concurrent pleural attachment and indentation are risk factors for VPI, and the odds increase with larger solid portion in subsolid nodules. Considering the risk of recurrence, early surgical resection could be encouraged in these patients. Korean Cancer Association 2019-10 2019-03-25 /pmc/articles/PMC6790827/ /pubmed/30913858 http://dx.doi.org/10.4143/crt.2019.057 Text en Copyright © 2019 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyung-Jun
Cho, Jun Yeun
Lee, Yeon Joo
Park, Jong Sun
Cho, Young-Jae
Yoon, Ho Il
Chung, Jin-Haeng
Cho, Sukki
Kim, Kwhanmien
Lee, Kyung Won
Lee, Jae Ho
Lee, Choon-Taek
Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
title Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
title_full Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
title_fullStr Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
title_full_unstemmed Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
title_short Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
title_sort clinical significance of pleural attachment and indentation of subsolid nodule lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790827/
https://www.ncbi.nlm.nih.gov/pubmed/30913858
http://dx.doi.org/10.4143/crt.2019.057
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