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Genetic aspects of type 1 diabetes

Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial ro...

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Detalles Bibliográficos
Autores principales: Lee, Hae Sang, Hwang, Jin Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Pediatric Endocrinology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790877/
https://www.ncbi.nlm.nih.gov/pubmed/31607106
http://dx.doi.org/10.6065/apem.2019.24.3.143
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author Lee, Hae Sang
Hwang, Jin Soon
author_facet Lee, Hae Sang
Hwang, Jin Soon
author_sort Lee, Hae Sang
collection PubMed
description Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM.
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spelling pubmed-67908772019-10-21 Genetic aspects of type 1 diabetes Lee, Hae Sang Hwang, Jin Soon Ann Pediatr Endocrinol Metab Review Article Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM. Korean Society of Pediatric Endocrinology 2019-09 2019-09-30 /pmc/articles/PMC6790877/ /pubmed/31607106 http://dx.doi.org/10.6065/apem.2019.24.3.143 Text en © 2019 Annals of Pediatric Endocrinology & Metabolism This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Hae Sang
Hwang, Jin Soon
Genetic aspects of type 1 diabetes
title Genetic aspects of type 1 diabetes
title_full Genetic aspects of type 1 diabetes
title_fullStr Genetic aspects of type 1 diabetes
title_full_unstemmed Genetic aspects of type 1 diabetes
title_short Genetic aspects of type 1 diabetes
title_sort genetic aspects of type 1 diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790877/
https://www.ncbi.nlm.nih.gov/pubmed/31607106
http://dx.doi.org/10.6065/apem.2019.24.3.143
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