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Genetic aspects of type 1 diabetes
Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial ro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Pediatric Endocrinology
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790877/ https://www.ncbi.nlm.nih.gov/pubmed/31607106 http://dx.doi.org/10.6065/apem.2019.24.3.143 |
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author | Lee, Hae Sang Hwang, Jin Soon |
author_facet | Lee, Hae Sang Hwang, Jin Soon |
author_sort | Lee, Hae Sang |
collection | PubMed |
description | Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM. |
format | Online Article Text |
id | pubmed-6790877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society of Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-67908772019-10-21 Genetic aspects of type 1 diabetes Lee, Hae Sang Hwang, Jin Soon Ann Pediatr Endocrinol Metab Review Article Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM. Korean Society of Pediatric Endocrinology 2019-09 2019-09-30 /pmc/articles/PMC6790877/ /pubmed/31607106 http://dx.doi.org/10.6065/apem.2019.24.3.143 Text en © 2019 Annals of Pediatric Endocrinology & Metabolism This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lee, Hae Sang Hwang, Jin Soon Genetic aspects of type 1 diabetes |
title | Genetic aspects of type 1 diabetes |
title_full | Genetic aspects of type 1 diabetes |
title_fullStr | Genetic aspects of type 1 diabetes |
title_full_unstemmed | Genetic aspects of type 1 diabetes |
title_short | Genetic aspects of type 1 diabetes |
title_sort | genetic aspects of type 1 diabetes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790877/ https://www.ncbi.nlm.nih.gov/pubmed/31607106 http://dx.doi.org/10.6065/apem.2019.24.3.143 |
work_keys_str_mv | AT leehaesang geneticaspectsoftype1diabetes AT hwangjinsoon geneticaspectsoftype1diabetes |