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Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly
OBJECTIVE: The aim of this study was to analyze the predictive value of preoperative laboratory findings in acute appendicitis in geriatric patients aged >65 years. METHODS: We enrolled a total of 4121 patients. A retrospective evaluation of the demographic features was made using preoperative la...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kare Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790928/ https://www.ncbi.nlm.nih.gov/pubmed/31650118 http://dx.doi.org/10.14744/nci.2019.93457 |
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author | Bayrak, Savas Tatar, Cihad Cakar, Ekrem Colak, Sukru Gunes, Mehmet Emin Tekesin, Kemal Gurbulak, Bunyamin Kinaci, Erdem Sevinc, Mert Mahsuni |
author_facet | Bayrak, Savas Tatar, Cihad Cakar, Ekrem Colak, Sukru Gunes, Mehmet Emin Tekesin, Kemal Gurbulak, Bunyamin Kinaci, Erdem Sevinc, Mert Mahsuni |
author_sort | Bayrak, Savas |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to analyze the predictive value of preoperative laboratory findings in acute appendicitis in geriatric patients aged >65 years. METHODS: We enrolled a total of 4121 patients. A retrospective evaluation of the demographic features was made using preoperative laboratory values such as the white blood cell (WBC), neutrophil, and lymphocyte counts; platelet counts; the mean platelet volume and bilirubin values; and postoperative pathological data of the patients from the electronic file system. The neutrophil-to-WBC and neutrophil-to-lymphocyte ratios were calculated. Patients were divided into two groups, as geriatric (≥65 years old, n=140) and non-geriatric (<65 years old, n=3981). RESULTS: The white blood cell and lymphocyte counts, and the neutrophil-to-WBC ratio, were significantly higher in the non-geriatric group (p<0.001, p=0.013, and p=0.021, respectively). The neutrophil and platelet counts were higher in the non-geriatric group, but this difference was not statistically significant (p=0.073 and p=0.072, respectively). A higher neutrophil-to-lymphocyte ratio was determined in the geriatric group, but the difference was not significant (p=0.176). According to the optimumal cutoff value of 12.11×10(3)/µL for WBC, specificity and sensitivity values of 65.4% and 57.9% were calculated, respectively; the AUC value was 0.632±0.024 (p<0.001). A receiver operating characteristic (ROC) analysis was used to calculate the optimum cutoff values of neutrophil-to-WBC ratio, lymphocyte, and the mean platelet volume, but the diagnostic accuracy of these tests was inadequate with an AUC of <0.6. CONCLUSION: WBC values >12.11×10(3)/µL were predictive of acute appendicitis in geriatric patients. The other parameters were not predictive, and further studies are required. |
format | Online Article Text |
id | pubmed-6790928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Kare Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-67909282019-10-24 Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly Bayrak, Savas Tatar, Cihad Cakar, Ekrem Colak, Sukru Gunes, Mehmet Emin Tekesin, Kemal Gurbulak, Bunyamin Kinaci, Erdem Sevinc, Mert Mahsuni North Clin Istanb Original Article OBJECTIVE: The aim of this study was to analyze the predictive value of preoperative laboratory findings in acute appendicitis in geriatric patients aged >65 years. METHODS: We enrolled a total of 4121 patients. A retrospective evaluation of the demographic features was made using preoperative laboratory values such as the white blood cell (WBC), neutrophil, and lymphocyte counts; platelet counts; the mean platelet volume and bilirubin values; and postoperative pathological data of the patients from the electronic file system. The neutrophil-to-WBC and neutrophil-to-lymphocyte ratios were calculated. Patients were divided into two groups, as geriatric (≥65 years old, n=140) and non-geriatric (<65 years old, n=3981). RESULTS: The white blood cell and lymphocyte counts, and the neutrophil-to-WBC ratio, were significantly higher in the non-geriatric group (p<0.001, p=0.013, and p=0.021, respectively). The neutrophil and platelet counts were higher in the non-geriatric group, but this difference was not statistically significant (p=0.073 and p=0.072, respectively). A higher neutrophil-to-lymphocyte ratio was determined in the geriatric group, but the difference was not significant (p=0.176). According to the optimumal cutoff value of 12.11×10(3)/µL for WBC, specificity and sensitivity values of 65.4% and 57.9% were calculated, respectively; the AUC value was 0.632±0.024 (p<0.001). A receiver operating characteristic (ROC) analysis was used to calculate the optimum cutoff values of neutrophil-to-WBC ratio, lymphocyte, and the mean platelet volume, but the diagnostic accuracy of these tests was inadequate with an AUC of <0.6. CONCLUSION: WBC values >12.11×10(3)/µL were predictive of acute appendicitis in geriatric patients. The other parameters were not predictive, and further studies are required. Kare Publishing 2019-07-08 /pmc/articles/PMC6790928/ /pubmed/31650118 http://dx.doi.org/10.14744/nci.2019.93457 Text en Copyright: © 2019 by Istanbul Northern Anatolian Association of Public Hospitals http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Original Article Bayrak, Savas Tatar, Cihad Cakar, Ekrem Colak, Sukru Gunes, Mehmet Emin Tekesin, Kemal Gurbulak, Bunyamin Kinaci, Erdem Sevinc, Mert Mahsuni Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
title | Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
title_full | Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
title_fullStr | Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
title_full_unstemmed | Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
title_short | Evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
title_sort | evaluation of the predictive power of laboratory markers in the diagnosis of acute appendicitis in the elderly |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790928/ https://www.ncbi.nlm.nih.gov/pubmed/31650118 http://dx.doi.org/10.14744/nci.2019.93457 |
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