A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating, motor neuron degenerative disease without any cure. About 95% of the ALS patients feature abnormalities in the RNA/DNA-binding protein, TDP-43, involving its nucleo-cytoplasmic mislocalization in spinal motor neurons. How TDP-43 pathology trigger...

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Detalles Bibliográficos
Autores principales: Mitra, Joy, Hegde, Muralidhar L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791036/
https://www.ncbi.nlm.nih.gov/pubmed/31656396
http://dx.doi.org/10.1177/1179069519880166

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