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Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles

Furosemide (FSM) is commonly used in the treatment of edema associated with congestive cardiac failure, cirrhosis of the liver, renal disease, including the nephrotic syndrome and hypertension. However, in ascites, it is clinically limited due to its frequent dosing and short biological half-life an...

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Autores principales: Kashyap, Sapna, Singh, Amit, Mishra, Abha, Singh, Vikas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791168/
https://www.ncbi.nlm.nih.gov/pubmed/31620185
http://dx.doi.org/10.4103/1735-5362.253356
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author Kashyap, Sapna
Singh, Amit
Mishra, Abha
Singh, Vikas
author_facet Kashyap, Sapna
Singh, Amit
Mishra, Abha
Singh, Vikas
author_sort Kashyap, Sapna
collection PubMed
description Furosemide (FSM) is commonly used in the treatment of edema associated with congestive cardiac failure, cirrhosis of the liver, renal disease, including the nephrotic syndrome and hypertension. However, in ascites, it is clinically limited due to its frequent dosing and short biological half-life and its prolonged-release preparations are not available. Therefore, the main objective behind the present research work is to develop chitosan coated and conjugated poly (lactic-co-glycolic acid) (PLGA) nanocarriers, to sustain the delivery of FSM with improved systemic circulation. Emulsion-solvent evaporation technique was used for the preparation of nanoparticles. In-vivo pharmacokinetic study showed 2.6, 3.10, and 4.30 folds enhancement in relative availability of FSM for FSM-PLGA, FSM-chitosan-coated-PLGA and FSM-chitosan-conjugated- PLGA nanoparticles, respectively than FSM. The present research work concluded that FSM loaded chitosan conjugated PLGA nanoparticles could enhance the systemic circulation of FSM with improved pharmacokinetics parameters.
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spelling pubmed-67911682019-10-16 Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles Kashyap, Sapna Singh, Amit Mishra, Abha Singh, Vikas Res Pharm Sci Original Article Furosemide (FSM) is commonly used in the treatment of edema associated with congestive cardiac failure, cirrhosis of the liver, renal disease, including the nephrotic syndrome and hypertension. However, in ascites, it is clinically limited due to its frequent dosing and short biological half-life and its prolonged-release preparations are not available. Therefore, the main objective behind the present research work is to develop chitosan coated and conjugated poly (lactic-co-glycolic acid) (PLGA) nanocarriers, to sustain the delivery of FSM with improved systemic circulation. Emulsion-solvent evaporation technique was used for the preparation of nanoparticles. In-vivo pharmacokinetic study showed 2.6, 3.10, and 4.30 folds enhancement in relative availability of FSM for FSM-PLGA, FSM-chitosan-coated-PLGA and FSM-chitosan-conjugated- PLGA nanoparticles, respectively than FSM. The present research work concluded that FSM loaded chitosan conjugated PLGA nanoparticles could enhance the systemic circulation of FSM with improved pharmacokinetics parameters. Wolters Kluwer - Medknow 2019-03-08 /pmc/articles/PMC6791168/ /pubmed/31620185 http://dx.doi.org/10.4103/1735-5362.253356 Text en Copyright: © 2019 Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kashyap, Sapna
Singh, Amit
Mishra, Abha
Singh, Vikas
Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
title Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
title_full Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
title_fullStr Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
title_full_unstemmed Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
title_short Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
title_sort enhanced sustained release of furosemide in long circulating chitosan-conjugated plga nanoparticles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791168/
https://www.ncbi.nlm.nih.gov/pubmed/31620185
http://dx.doi.org/10.4103/1735-5362.253356
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