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Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy

Cardiac-cerebral thrombosis and malignant tumor endanger the safety of human life seriously. Traditional chemotherapy drugs have side effects which restrict their applications. Drug-loaded microbubbles can be destroyed by ultrasound irradiation at the focus position and be used for thrombolysis and...

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Autores principales: Gong, Qian, Gao, Xingxing, Liu, Wenfang, Hong, Tingting, Chen, Chuanpin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791276/
https://www.ncbi.nlm.nih.gov/pubmed/31662987
http://dx.doi.org/10.1155/2019/6792465
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author Gong, Qian
Gao, Xingxing
Liu, Wenfang
Hong, Tingting
Chen, Chuanpin
author_facet Gong, Qian
Gao, Xingxing
Liu, Wenfang
Hong, Tingting
Chen, Chuanpin
author_sort Gong, Qian
collection PubMed
description Cardiac-cerebral thrombosis and malignant tumor endanger the safety of human life seriously. Traditional chemotherapy drugs have side effects which restrict their applications. Drug-loaded microbubbles can be destroyed by ultrasound irradiation at the focus position and be used for thrombolysis and tumor therapy. Compared with traditional drug treatment, the drug-loaded microbubbles can be excited by ultrasound and release drugs to lesion sites, increasing the local drug concentration and the exposure dose to nonfocal regions, thus reducing the cytotoxicity and side effects of drugs. This article reviews the applications of drug-loaded microbubbles combined with ultrasound for thrombolysis and tumor therapy. We focus on highlighting the advantages of using this new technique for disease treatment and concluding with recommendations for future efforts on the applications of this technology.
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spelling pubmed-67912762019-10-29 Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy Gong, Qian Gao, Xingxing Liu, Wenfang Hong, Tingting Chen, Chuanpin Biomed Res Int Review Article Cardiac-cerebral thrombosis and malignant tumor endanger the safety of human life seriously. Traditional chemotherapy drugs have side effects which restrict their applications. Drug-loaded microbubbles can be destroyed by ultrasound irradiation at the focus position and be used for thrombolysis and tumor therapy. Compared with traditional drug treatment, the drug-loaded microbubbles can be excited by ultrasound and release drugs to lesion sites, increasing the local drug concentration and the exposure dose to nonfocal regions, thus reducing the cytotoxicity and side effects of drugs. This article reviews the applications of drug-loaded microbubbles combined with ultrasound for thrombolysis and tumor therapy. We focus on highlighting the advantages of using this new technique for disease treatment and concluding with recommendations for future efforts on the applications of this technology. Hindawi 2019-10-01 /pmc/articles/PMC6791276/ /pubmed/31662987 http://dx.doi.org/10.1155/2019/6792465 Text en Copyright © 2019 Qian Gong et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gong, Qian
Gao, Xingxing
Liu, Wenfang
Hong, Tingting
Chen, Chuanpin
Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
title Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
title_full Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
title_fullStr Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
title_full_unstemmed Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
title_short Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
title_sort drug-loaded microbubbles combined with ultrasound for thrombolysis and malignant tumor therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791276/
https://www.ncbi.nlm.nih.gov/pubmed/31662987
http://dx.doi.org/10.1155/2019/6792465
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