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Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA

[Image: see text] The c-MYC transcription factor is a master regulator of cell growth and proliferation and is an established target for cancer therapy. This basic helix–loop–helix Zip protein forms a heterodimer with its obligatory partner MAX, which binds to DNA via the basic region. Considerable...

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Detalles Bibliográficos
Autores principales:	Sammak, Susan, Hamdani, Najoua, Gorrec, Fabrice, Allen, Mark D., Freund, Stefan M. V., Bycroft, Mark, Zinzalla, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791285/ https://www.ncbi.nlm.nih.gov/pubmed/31260268 http://dx.doi.org/10.1021/acs.biochem.9b00296

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