Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response

Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemi...

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Detalles Bibliográficos
Autores principales: Sosnowska, Anna, Czystowska-Kuzmicz, Malgorzata, Golab, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791438/
https://www.ncbi.nlm.nih.gov/pubmed/31646104
http://dx.doi.org/10.1080/2162402X.2019.1655370
Descripción
Sumario:Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemic immune suppression, which can be restored by ARG inhibitor.

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