Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response

Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemi...

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Autores principales: Sosnowska, Anna, Czystowska-Kuzmicz, Malgorzata, Golab, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791438/
https://www.ncbi.nlm.nih.gov/pubmed/31646104
http://dx.doi.org/10.1080/2162402X.2019.1655370
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author Sosnowska, Anna
Czystowska-Kuzmicz, Malgorzata
Golab, Jakub
author_facet Sosnowska, Anna
Czystowska-Kuzmicz, Malgorzata
Golab, Jakub
author_sort Sosnowska, Anna
collection PubMed
description Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemic immune suppression, which can be restored by ARG inhibitor.
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spelling pubmed-67914382019-10-23 Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response Sosnowska, Anna Czystowska-Kuzmicz, Malgorzata Golab, Jakub Oncoimmunology Author's View Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemic immune suppression, which can be restored by ARG inhibitor. Taylor & Francis 2019-08-20 /pmc/articles/PMC6791438/ /pubmed/31646104 http://dx.doi.org/10.1080/2162402X.2019.1655370 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Sosnowska, Anna
Czystowska-Kuzmicz, Malgorzata
Golab, Jakub
Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
title Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
title_full Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
title_fullStr Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
title_full_unstemmed Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
title_short Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
title_sort extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791438/
https://www.ncbi.nlm.nih.gov/pubmed/31646104
http://dx.doi.org/10.1080/2162402X.2019.1655370
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AT golabjakub extracellularvesiclesreleasedbyovariancarcinomacontainarginase1thatmitigatesantitumorimmuneresponse

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