Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve th...

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Detalles Bibliográficos
Autores principales: Verdura, Sara, Cuyàs, Elisabet, Martin-Castillo, Begoña, Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791450/
https://www.ncbi.nlm.nih.gov/pubmed/31646077
http://dx.doi.org/10.1080/2162402X.2019.1633235
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author Verdura, Sara
Cuyàs, Elisabet
Martin-Castillo, Begoña
Menendez, Javier A.
author_facet Verdura, Sara
Cuyàs, Elisabet
Martin-Castillo, Begoña
Menendez, Javier A.
author_sort Verdura, Sara
collection PubMed
description The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions.
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spelling pubmed-67914502019-10-23 Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy Verdura, Sara Cuyàs, Elisabet Martin-Castillo, Begoña Menendez, Javier A. Oncoimmunology Point-of-View The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions. Taylor & Francis 2019-06-25 /pmc/articles/PMC6791450/ /pubmed/31646077 http://dx.doi.org/10.1080/2162402X.2019.1633235 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Verdura, Sara
Cuyàs, Elisabet
Martin-Castillo, Begoña
Menendez, Javier A.
Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
title Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
title_full Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
title_fullStr Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
title_full_unstemmed Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
title_short Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
title_sort metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791450/
https://www.ncbi.nlm.nih.gov/pubmed/31646077
http://dx.doi.org/10.1080/2162402X.2019.1633235
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AT menendezjaviera metforminasanarchetypeimmunometabolicadjuvantforcancerimmunotherapy

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