Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

In patients with cancer, the functionality of Dendritic Cells (DC) is hampered by high levels of tumor-derived suppressive cytokines, which interfere with DC development and maturation. Poor DC development can limit the efficacy of immune checkpoint blockade and in vivo vaccination approaches. Inter...

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Detalles Bibliográficos
Autores principales: López González, Marta, Oosterhoff, Dinja, Lindenberg, Jelle J., Milenova, Ioanna, Lougheed, Sinead M., Martiáñez, Tania, Dekker, Henk, Quixabeira, Dafne Carolina Alves, Hangalapura, Basav, Joore, Jos, Piersma, Sander R., Cervera-Carrascon, Victor, Santos, Joao Manuel, Scheper, Rik J., Verheul, Henk M.W., Jiménez, Connie R., Van De Ven, Rieneke, Hemminki, Akseli, Van Beusechem, Victor W., De Gruijl, Tanja D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791458/
https://www.ncbi.nlm.nih.gov/pubmed/31646076
http://dx.doi.org/10.1080/2162402X.2019.1631119

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