T Helper 9 Cells: A New Player in Immune-Related Diseases

The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4(+)T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cyt...

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Detalles Bibliográficos
Autores principales: Chen, Jing, Guan, Lian, Tang, Lin, Liu, Shiming, Zhou, Ya, Chen, Chao, He, Zhixu, Xu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791470/
https://www.ncbi.nlm.nih.gov/pubmed/31414895
http://dx.doi.org/10.1089/dna.2019.4729
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author Chen, Jing
Guan, Lian
Tang, Lin
Liu, Shiming
Zhou, Ya
Chen, Chao
He, Zhixu
Xu, Lin
author_facet Chen, Jing
Guan, Lian
Tang, Lin
Liu, Shiming
Zhou, Ya
Chen, Chao
He, Zhixu
Xu, Lin
author_sort Chen, Jing
collection PubMed
description The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4(+)T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cytokine transforming growth factor β, IL-4, and various transcription factors. Th9 cells, as a new player, played an important role in various immune-related diseases, including tumors, inflammatory diseases, parasite infection, and other diseases. In this article, we summarize the related research progress and discuss the possible prospect.
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spelling pubmed-67914702019-10-15 T Helper 9 Cells: A New Player in Immune-Related Diseases Chen, Jing Guan, Lian Tang, Lin Liu, Shiming Zhou, Ya Chen, Chao He, Zhixu Xu, Lin DNA Cell Biol Reviews The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4(+)T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cytokine transforming growth factor β, IL-4, and various transcription factors. Th9 cells, as a new player, played an important role in various immune-related diseases, including tumors, inflammatory diseases, parasite infection, and other diseases. In this article, we summarize the related research progress and discuss the possible prospect. Mary Ann Liebert, Inc., publishers 2019-10-01 2019-10-07 /pmc/articles/PMC6791470/ /pubmed/31414895 http://dx.doi.org/10.1089/dna.2019.4729 Text en © Jing Chen et al., 2019; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Chen, Jing
Guan, Lian
Tang, Lin
Liu, Shiming
Zhou, Ya
Chen, Chao
He, Zhixu
Xu, Lin
T Helper 9 Cells: A New Player in Immune-Related Diseases
title T Helper 9 Cells: A New Player in Immune-Related Diseases
title_full T Helper 9 Cells: A New Player in Immune-Related Diseases
title_fullStr T Helper 9 Cells: A New Player in Immune-Related Diseases
title_full_unstemmed T Helper 9 Cells: A New Player in Immune-Related Diseases
title_short T Helper 9 Cells: A New Player in Immune-Related Diseases
title_sort t helper 9 cells: a new player in immune-related diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791470/
https://www.ncbi.nlm.nih.gov/pubmed/31414895
http://dx.doi.org/10.1089/dna.2019.4729
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