N-Acetylcysteine in the Management of Acute Liver Failure From Sickle Cell Hepatic Crisis

N-acetylcysteine (NAC) has been well studied in the treatment of acetaminophen-induced and select non-acetaminophen-induced liver failure. However, its role in the management of sickle cell hepatic crisis resulting in acute liver failure (ALF) is unknown. We describe and discuss the novel and benefi...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaojie, Burroughs, Sarah, Farooq, Ahmad, Bashir, Mustafa R., Muir, Andrew J., Patel, Yuval A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791608/
https://www.ncbi.nlm.nih.gov/pubmed/31737700
http://dx.doi.org/10.14309/crj.0000000000000161
Descripción
Sumario:N-acetylcysteine (NAC) has been well studied in the treatment of acetaminophen-induced and select non-acetaminophen-induced liver failure. However, its role in the management of sickle cell hepatic crisis resulting in acute liver failure (ALF) is unknown. We describe and discuss the novel and beneficial use of NAC in a 25-year-old man with ALF due to sickle cell hepatic crisis. We further review ALF in sickle cell disease and NAC in the treatment of non-acetaminophen-induced liver failure. Our case highlights the promising role of NAC in sickle cell-related liver injury.

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