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Idiosyncratic Liver Injury Due to Levocetirizine

Levocetirizine is an over-the-counter nonsedating antihistaminic agent commonly used to treat allergic diseases. Clinically significant acute liver injury has been very rarely associated with its use. Only 2 cases of acute liver injury associated with levocetirizine have been reported in the literat...

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Autores principales: Annunziata, Giuseppe, Mayuko, Imai, Barbara, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791624/
https://www.ncbi.nlm.nih.gov/pubmed/31737721
http://dx.doi.org/10.14309/crj.0000000000000191
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author Annunziata, Giuseppe
Mayuko, Imai
Barbara, Mary
author_facet Annunziata, Giuseppe
Mayuko, Imai
Barbara, Mary
author_sort Annunziata, Giuseppe
collection PubMed
description Levocetirizine is an over-the-counter nonsedating antihistaminic agent commonly used to treat allergic diseases. Clinically significant acute liver injury has been very rarely associated with its use. Only 2 cases of acute liver injury associated with levocetirizine have been reported in the literature. We describe the case of a 67-year-old man who developed clinically significant acute hepatic injury after using levocetirizine. On the liver biopsy, there were histological findings of periportal inflammation and prominent cholestatic injury; such findings are consistent with those previously described in another similar case.
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spelling pubmed-67916242019-11-15 Idiosyncratic Liver Injury Due to Levocetirizine Annunziata, Giuseppe Mayuko, Imai Barbara, Mary ACG Case Rep J Case Report Levocetirizine is an over-the-counter nonsedating antihistaminic agent commonly used to treat allergic diseases. Clinically significant acute liver injury has been very rarely associated with its use. Only 2 cases of acute liver injury associated with levocetirizine have been reported in the literature. We describe the case of a 67-year-old man who developed clinically significant acute hepatic injury after using levocetirizine. On the liver biopsy, there were histological findings of periportal inflammation and prominent cholestatic injury; such findings are consistent with those previously described in another similar case. Wolters Kluwer 2019-08-27 /pmc/articles/PMC6791624/ /pubmed/31737721 http://dx.doi.org/10.14309/crj.0000000000000191 Text en © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Annunziata, Giuseppe
Mayuko, Imai
Barbara, Mary
Idiosyncratic Liver Injury Due to Levocetirizine
title Idiosyncratic Liver Injury Due to Levocetirizine
title_full Idiosyncratic Liver Injury Due to Levocetirizine
title_fullStr Idiosyncratic Liver Injury Due to Levocetirizine
title_full_unstemmed Idiosyncratic Liver Injury Due to Levocetirizine
title_short Idiosyncratic Liver Injury Due to Levocetirizine
title_sort idiosyncratic liver injury due to levocetirizine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791624/
https://www.ncbi.nlm.nih.gov/pubmed/31737721
http://dx.doi.org/10.14309/crj.0000000000000191
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