Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin

The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA...

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Detalles Bibliográficos
Autores principales: Park, Kyo-Hyun, Kim, JiYeon, Jung, Suryun, Sung, Kyung-hwa, Son, Yeon-Kyoung, Bae, Jung Min, Kim, Bae-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Toxicology 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791660/
https://www.ncbi.nlm.nih.gov/pubmed/31636846
http://dx.doi.org/10.5487/TR.2019.35.4.353
Descripción
Sumario:The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA™ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGA™ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGA™ 500. Therefore, the intake of 7-MEGA™ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.

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