Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin

The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA...

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Autores principales: Park, Kyo-Hyun, Kim, JiYeon, Jung, Suryun, Sung, Kyung-hwa, Son, Yeon-Kyoung, Bae, Jung Min, Kim, Bae-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Toxicology 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791660/
https://www.ncbi.nlm.nih.gov/pubmed/31636846
http://dx.doi.org/10.5487/TR.2019.35.4.353
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author Park, Kyo-Hyun
Kim, JiYeon
Jung, Suryun
Sung, Kyung-hwa
Son, Yeon-Kyoung
Bae, Jung Min
Kim, Bae-Hwan
author_facet Park, Kyo-Hyun
Kim, JiYeon
Jung, Suryun
Sung, Kyung-hwa
Son, Yeon-Kyoung
Bae, Jung Min
Kim, Bae-Hwan
author_sort Park, Kyo-Hyun
collection PubMed
description The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA™ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGA™ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGA™ 500. Therefore, the intake of 7-MEGA™ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.
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spelling pubmed-67916602019-10-21 Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin Park, Kyo-Hyun Kim, JiYeon Jung, Suryun Sung, Kyung-hwa Son, Yeon-Kyoung Bae, Jung Min Kim, Bae-Hwan Toxicol Res Original Article The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA™ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGA™ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGA™ 500. Therefore, the intake of 7-MEGA™ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed. Korean Society of Toxicology 2019-10 2019-10-15 /pmc/articles/PMC6791660/ /pubmed/31636846 http://dx.doi.org/10.5487/TR.2019.35.4.353 Text en Copyright © 2019 The Korean Society Of Toxicology http://creativecommons.org/licenses/by-nc/3.0 This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Kyo-Hyun
Kim, JiYeon
Jung, Suryun
Sung, Kyung-hwa
Son, Yeon-Kyoung
Bae, Jung Min
Kim, Bae-Hwan
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin
title Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin
title_full Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin
title_fullStr Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin
title_full_unstemmed Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin
title_short Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGA(TM) 500 in Hairless Mouse Skin
title_sort alleviation of ultraviolet b-induced photoaging by 7-mega(tm) 500 in hairless mouse skin
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791660/
https://www.ncbi.nlm.nih.gov/pubmed/31636846
http://dx.doi.org/10.5487/TR.2019.35.4.353
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