Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

Small heat shock proteins (sHSPs) are nature’s ‘first responders’ to cellular stress, interacting with affected proteins to prevent their aggregation. Little is known about sHSP structure beyond its structured α-crystallin domain (ACD), which is flanked by disordered regions. In the human sHSP HSPB1...

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Detalles Bibliográficos
Autores principales: Clouser, Amanda F, Baughman, Hannah ER, Basanta, Benjamin, Guttman, Miklos, Nath, Abhinav, Klevit, Rachel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791718/
https://www.ncbi.nlm.nih.gov/pubmed/31573509
http://dx.doi.org/10.7554/eLife.50259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791718/
https://www.ncbi.nlm.nih.gov/pubmed/31573509
http://dx.doi.org/10.7554/eLife.50259

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