Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization

Sensitive and specific DNA hybridization is essential for nucleic acid chemistry. Competitive composition of probe and blocker has been the most adopted probe design for its relatively high sensitivity and specificity. However, the sensitivity and specificity were inversely correlated over the lengt...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Liu, Na, Liu, Liquan, Chen, Wei, Chen, Na, Lin, Meng, Xu, Jiaju, Zhou, Xing, Wang, Hongbo, Zhao, Meiping, Xiao, Xianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791858/
https://www.ncbi.nlm.nih.gov/pubmed/31611572
http://dx.doi.org/10.1038/s41467-019-12593-9

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