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Characterization of biological variation of peripheral blood immune cytome in an Indian cohort
Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy you...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791881/ https://www.ncbi.nlm.nih.gov/pubmed/31611580 http://dx.doi.org/10.1038/s41598-019-51294-7 |
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author | Kanodia, Parna Kaur, Gurvinder Coshic, Poonam Chatterjee, Kabita Neeman, Teresa George, Anna Rath, Satyajit Bal, Vineeta Prabhu, Savit B. |
author_facet | Kanodia, Parna Kaur, Gurvinder Coshic, Poonam Chatterjee, Kabita Neeman, Teresa George, Anna Rath, Satyajit Bal, Vineeta Prabhu, Savit B. |
author_sort | Kanodia, Parna |
collection | PubMed |
description | Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers. Our analysis revealed that immune subsets that showed low variability between individuals also showed low short-term fluctuations within-individuals, as well as concordance in siblings. However, when baseline levels and degree of fluctuation were considered together, individuals failed to cluster into discreet groups. Together, the data reveal complex inter-relationships between immune subsets in individuals, and provide insights into the observed heterogeneity between individuals and between multiple immune subsets. |
format | Online Article Text |
id | pubmed-6791881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67918812019-10-21 Characterization of biological variation of peripheral blood immune cytome in an Indian cohort Kanodia, Parna Kaur, Gurvinder Coshic, Poonam Chatterjee, Kabita Neeman, Teresa George, Anna Rath, Satyajit Bal, Vineeta Prabhu, Savit B. Sci Rep Article Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers. Our analysis revealed that immune subsets that showed low variability between individuals also showed low short-term fluctuations within-individuals, as well as concordance in siblings. However, when baseline levels and degree of fluctuation were considered together, individuals failed to cluster into discreet groups. Together, the data reveal complex inter-relationships between immune subsets in individuals, and provide insights into the observed heterogeneity between individuals and between multiple immune subsets. Nature Publishing Group UK 2019-10-14 /pmc/articles/PMC6791881/ /pubmed/31611580 http://dx.doi.org/10.1038/s41598-019-51294-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kanodia, Parna Kaur, Gurvinder Coshic, Poonam Chatterjee, Kabita Neeman, Teresa George, Anna Rath, Satyajit Bal, Vineeta Prabhu, Savit B. Characterization of biological variation of peripheral blood immune cytome in an Indian cohort |
title | Characterization of biological variation of peripheral blood immune cytome in an Indian cohort |
title_full | Characterization of biological variation of peripheral blood immune cytome in an Indian cohort |
title_fullStr | Characterization of biological variation of peripheral blood immune cytome in an Indian cohort |
title_full_unstemmed | Characterization of biological variation of peripheral blood immune cytome in an Indian cohort |
title_short | Characterization of biological variation of peripheral blood immune cytome in an Indian cohort |
title_sort | characterization of biological variation of peripheral blood immune cytome in an indian cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791881/ https://www.ncbi.nlm.nih.gov/pubmed/31611580 http://dx.doi.org/10.1038/s41598-019-51294-7 |
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