Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression

E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S‐phase entry and progression. Previously, we demonstrated that these atypical E2Fs are degraded by APC/C(C) (dh1) during G1 phase of the cell cycle. However, the mechanism driving the downregulation of atypic...

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Detalles Bibliográficos
Autores principales: Yuan, Ruixue, Liu, Qingwu, Segeren, Hendrika A, Yuniati, Laurensia, Guardavaccaro, Daniele, Lebbink, Robert J, Westendorp, Bart, de Bruin, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792010/
https://www.ncbi.nlm.nih.gov/pubmed/31475738
http://dx.doi.org/10.15252/embj.2018101430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792010/
https://www.ncbi.nlm.nih.gov/pubmed/31475738
http://dx.doi.org/10.15252/embj.2018101430

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