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Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses

Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R178E mutation into the Trp53 gene of mice to specifically ablate the cooperative nature of p53 DNA binding. Trp53 (R178E) mice show no detectable target...

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Detalles Bibliográficos
Autores principales:	Timofeev, Oleg, Klimovich, Boris, Schneikert, Jean, Wanzel, Michael, Pavlakis, Evangelos, Noll, Julia, Mutlu, Samet, Elmshäuser, Sabrina, Nist, Andrea, Mernberger, Marco, Lamp, Boris, Wenig, Ulrich, Brobeil, Alexander, Gattenlöhner, Stefan, Köhler, Kernt, Stiewe, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792016/ https://www.ncbi.nlm.nih.gov/pubmed/31483066 http://dx.doi.org/10.15252/embj.2019102096

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