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A Biohistorical Perspective of Typhoid and Antimicrobial Resistance

We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typh...

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Detalles Bibliográficos
Autores principales: Kirchhelle, Claas, Dyson, Zoe Anne, Dougan, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792120/
https://www.ncbi.nlm.nih.gov/pubmed/31612939
http://dx.doi.org/10.1093/cid/ciz556
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author Kirchhelle, Claas
Dyson, Zoe Anne
Dougan, Gordon
author_facet Kirchhelle, Claas
Dyson, Zoe Anne
Dougan, Gordon
author_sort Kirchhelle, Claas
collection PubMed
description We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid’s cultural status as a supposedly ancient disease of “undeveloped” countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect.
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spelling pubmed-67921202019-10-21 A Biohistorical Perspective of Typhoid and Antimicrobial Resistance Kirchhelle, Claas Dyson, Zoe Anne Dougan, Gordon Clin Infect Dis Supplement Articles We combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid’s cultural status as a supposedly ancient disease of “undeveloped” countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect. Oxford University Press 2019-11-01 2019-10-15 /pmc/articles/PMC6792120/ /pubmed/31612939 http://dx.doi.org/10.1093/cid/ciz556 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Kirchhelle, Claas
Dyson, Zoe Anne
Dougan, Gordon
A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
title A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
title_full A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
title_fullStr A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
title_full_unstemmed A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
title_short A Biohistorical Perspective of Typhoid and Antimicrobial Resistance
title_sort biohistorical perspective of typhoid and antimicrobial resistance
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792120/
https://www.ncbi.nlm.nih.gov/pubmed/31612939
http://dx.doi.org/10.1093/cid/ciz556
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