Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates

[Image: see text] Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate its synthesis and derivatiz...

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Detalles Bibliográficos
Autores principales: Li, Wei, Veale, Karen H., Qiu, Qifeng, Sinkevicius, Kerstin W., Maloney, Erin K., Costoplus, Juliet A., Lau, Janet, Evans, Helen L., Setiady, Yulius, Ab, Olga, Abbott, Stephen M., Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A., Chari, Ravi V. J., Widdison, Wayne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792168/
https://www.ncbi.nlm.nih.gov/pubmed/31620223
http://dx.doi.org/10.1021/acsmedchemlett.9b00301

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