Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing

[Image: see text] A new type of antibody–drug conjugate (ADC) has been prepared that contains a sulfur-bearing maytansinoid attached to an antibody via a highly stable tripeptide linker. Once internalized by cells, proteases in catabolic vesicles cleave the peptide of the ADC’s linker causing self-i...

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Detalles Bibliográficos
Autores principales: Costoplus, Juliet A., Veale, Karen H., Qiu, Qifeng, Ponte, Jose F., Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Bartle, Laura M., Salomon, Paulin, Wu, Rui, Maloney, Erin K., Kovtun, Yelena V., Ab, Olga, Lai, Kate, Chari, Ravi V. J., Widdison, Wayne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792174/
https://www.ncbi.nlm.nih.gov/pubmed/31620224
http://dx.doi.org/10.1021/acsmedchemlett.9b00310

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