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New potentiometric sensors for methylphenidate detection based on host–guest interaction
The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8]arene as ionophores or electroactive materials have been used for...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792245/ https://www.ncbi.nlm.nih.gov/pubmed/31637370 http://dx.doi.org/10.1186/s13065-019-0634-3 |
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author | AlRabiah, Haitham Abounassif, Mohammed Aljohar, Haya I. Mostafa, Gamal Abdel-Hafiz |
author_facet | AlRabiah, Haitham Abounassif, Mohammed Aljohar, Haya I. Mostafa, Gamal Abdel-Hafiz |
author_sort | AlRabiah, Haitham |
collection | PubMed |
description | The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8]arene as ionophores or electroactive materials have been used for construction of sensors 1, 2, and 3, respectively; Potassium tetrakis (4-chlorophenyl)borate (KTpClPB) as an ion additive was used and dioctyl phthalate as a plasticizer. The sensors displayed a fast, stable response over a wide concentration range of methylphenidate (8 × 10(−6) M to 1 × 10(−3) M) with 10(−6) M detection limit over the pH range of 4–8. The developed sensors displayed a Near-Nernstian cationic response for methylphenidate at 59.5, 51.37, and 56.5 mV/decade for sensors β-CD, γ-CD, or 4-tertbutylcalix[8]arene respectively. Validation of the proposed sensors is supported by high accuracy, precision, stability, fast response, and long lifetimes, as well as selectivity for methylphenidate in the presence of different species. Sensitive and practical sensors for the determination of methylphenidate in bulk, in pharmaceutical forms and urine were developed and validated for routine laboratory use. The results were comparable to those obtained by HPLC method. |
format | Online Article Text |
id | pubmed-6792245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-67922452019-10-21 New potentiometric sensors for methylphenidate detection based on host–guest interaction AlRabiah, Haitham Abounassif, Mohammed Aljohar, Haya I. Mostafa, Gamal Abdel-Hafiz BMC Chem Research Article The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8]arene as ionophores or electroactive materials have been used for construction of sensors 1, 2, and 3, respectively; Potassium tetrakis (4-chlorophenyl)borate (KTpClPB) as an ion additive was used and dioctyl phthalate as a plasticizer. The sensors displayed a fast, stable response over a wide concentration range of methylphenidate (8 × 10(−6) M to 1 × 10(−3) M) with 10(−6) M detection limit over the pH range of 4–8. The developed sensors displayed a Near-Nernstian cationic response for methylphenidate at 59.5, 51.37, and 56.5 mV/decade for sensors β-CD, γ-CD, or 4-tertbutylcalix[8]arene respectively. Validation of the proposed sensors is supported by high accuracy, precision, stability, fast response, and long lifetimes, as well as selectivity for methylphenidate in the presence of different species. Sensitive and practical sensors for the determination of methylphenidate in bulk, in pharmaceutical forms and urine were developed and validated for routine laboratory use. The results were comparable to those obtained by HPLC method. Springer International Publishing 2019-10-14 /pmc/articles/PMC6792245/ /pubmed/31637370 http://dx.doi.org/10.1186/s13065-019-0634-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article AlRabiah, Haitham Abounassif, Mohammed Aljohar, Haya I. Mostafa, Gamal Abdel-Hafiz New potentiometric sensors for methylphenidate detection based on host–guest interaction |
title | New potentiometric sensors for methylphenidate detection based on host–guest interaction |
title_full | New potentiometric sensors for methylphenidate detection based on host–guest interaction |
title_fullStr | New potentiometric sensors for methylphenidate detection based on host–guest interaction |
title_full_unstemmed | New potentiometric sensors for methylphenidate detection based on host–guest interaction |
title_short | New potentiometric sensors for methylphenidate detection based on host–guest interaction |
title_sort | new potentiometric sensors for methylphenidate detection based on host–guest interaction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792245/ https://www.ncbi.nlm.nih.gov/pubmed/31637370 http://dx.doi.org/10.1186/s13065-019-0634-3 |
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