Cargando…

Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)

BACKGROUND: Identifying factors that impair bone accrual during childhood is a critical step toward osteoporosis prevention. Exposure to per- and polyfluoroalkyl substances (PFASs) has been associated with lower bone mineral density, but data are limited, particularly in children. METHODS: We studie...

Descripción completa

Detalles Bibliográficos
Autores principales: Cluett, Rachel, Seshasayee, Shravanthi M., Rokoff, Lisa B., Rifas-Shiman, Sheryl L., Ye, Xiaoyun, Calafat, Antonia M., Gold, Diane R., Coull, Brent, Gordon, Catherine M., Rosen, Clifford J., Oken, Emily, Sagiv, Sharon K., Fleisch, Abby F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792359/
https://www.ncbi.nlm.nih.gov/pubmed/31433236
http://dx.doi.org/10.1289/EHP4918
_version_ 1783459136890994688
author Cluett, Rachel
Seshasayee, Shravanthi M.
Rokoff, Lisa B.
Rifas-Shiman, Sheryl L.
Ye, Xiaoyun
Calafat, Antonia M.
Gold, Diane R.
Coull, Brent
Gordon, Catherine M.
Rosen, Clifford J.
Oken, Emily
Sagiv, Sharon K.
Fleisch, Abby F.
author_facet Cluett, Rachel
Seshasayee, Shravanthi M.
Rokoff, Lisa B.
Rifas-Shiman, Sheryl L.
Ye, Xiaoyun
Calafat, Antonia M.
Gold, Diane R.
Coull, Brent
Gordon, Catherine M.
Rosen, Clifford J.
Oken, Emily
Sagiv, Sharon K.
Fleisch, Abby F.
author_sort Cluett, Rachel
collection PubMed
description BACKGROUND: Identifying factors that impair bone accrual during childhood is a critical step toward osteoporosis prevention. Exposure to per- and polyfluoroalkyl substances (PFASs) has been associated with lower bone mineral density, but data are limited, particularly in children. METHODS: We studied 576 children in Project Viva, a Boston-area cohort of mother/child pairs recruited prenatally from 1999 to 2002. We quantified plasma concentrations of several PFASs and measured areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) in midchildhood. We used linear regression to examine associations between plasma concentrations of individual PFASs and aBMD z-score. We used weighted quantile sum (WQS) regression to examine the association of the PFAS mixture with aBMD z-score. All models were adjusted for maternal age, education, annual household income, census tract median household income, and child age, sex, race/ethnicity, dairy intake, physical activity, and year of blood draw. RESULTS: Children were [[Formula: see text]] [Formula: see text] of age. The highest PFAS plasma concentrations were of perfluorooctanesulfonic acid (PFOS) {median [interquartile range (IQR)]: 6.4 (5.6) ng/mL} and perfluorooctanoic acid (PFOA) [median (IQR): 4.4 (3.2) ng/mL]. Using linear regression, children with higher plasma concentrations of PFOA, PFOS, and perfluorodecanoate (PFDA) had lower aBMD z-scores [e.g., [Formula: see text]: [Formula: see text]; 95% confidence interval (CI): [Formula: see text] , [Formula: see text] per doubling of PFOA]. The PFAS mixture was negatively associated with aBMD z-score ([Formula: see text]: [Formula: see text]; 95% CI: [Formula: see text] , [Formula: see text] per IQR increment of the mixture index). CONCLUSIONS: PFAS exposure may impair bone accrual in childhood and peak bone mass, an important determinant of lifelong skeletal health. https://doi.org/10.1289/EHP4918
format Online
Article
Text
id pubmed-6792359
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Environmental Health Perspectives
record_format MEDLINE/PubMed
spelling pubmed-67923592019-11-06 Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States) Cluett, Rachel Seshasayee, Shravanthi M. Rokoff, Lisa B. Rifas-Shiman, Sheryl L. Ye, Xiaoyun Calafat, Antonia M. Gold, Diane R. Coull, Brent Gordon, Catherine M. Rosen, Clifford J. Oken, Emily Sagiv, Sharon K. Fleisch, Abby F. Environ Health Perspect Research BACKGROUND: Identifying factors that impair bone accrual during childhood is a critical step toward osteoporosis prevention. Exposure to per- and polyfluoroalkyl substances (PFASs) has been associated with lower bone mineral density, but data are limited, particularly in children. METHODS: We studied 576 children in Project Viva, a Boston-area cohort of mother/child pairs recruited prenatally from 1999 to 2002. We quantified plasma concentrations of several PFASs and measured areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) in midchildhood. We used linear regression to examine associations between plasma concentrations of individual PFASs and aBMD z-score. We used weighted quantile sum (WQS) regression to examine the association of the PFAS mixture with aBMD z-score. All models were adjusted for maternal age, education, annual household income, census tract median household income, and child age, sex, race/ethnicity, dairy intake, physical activity, and year of blood draw. RESULTS: Children were [[Formula: see text]] [Formula: see text] of age. The highest PFAS plasma concentrations were of perfluorooctanesulfonic acid (PFOS) {median [interquartile range (IQR)]: 6.4 (5.6) ng/mL} and perfluorooctanoic acid (PFOA) [median (IQR): 4.4 (3.2) ng/mL]. Using linear regression, children with higher plasma concentrations of PFOA, PFOS, and perfluorodecanoate (PFDA) had lower aBMD z-scores [e.g., [Formula: see text]: [Formula: see text]; 95% confidence interval (CI): [Formula: see text] , [Formula: see text] per doubling of PFOA]. The PFAS mixture was negatively associated with aBMD z-score ([Formula: see text]: [Formula: see text]; 95% CI: [Formula: see text] , [Formula: see text] per IQR increment of the mixture index). CONCLUSIONS: PFAS exposure may impair bone accrual in childhood and peak bone mass, an important determinant of lifelong skeletal health. https://doi.org/10.1289/EHP4918 Environmental Health Perspectives 2019-08-21 /pmc/articles/PMC6792359/ /pubmed/31433236 http://dx.doi.org/10.1289/EHP4918 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Cluett, Rachel
Seshasayee, Shravanthi M.
Rokoff, Lisa B.
Rifas-Shiman, Sheryl L.
Ye, Xiaoyun
Calafat, Antonia M.
Gold, Diane R.
Coull, Brent
Gordon, Catherine M.
Rosen, Clifford J.
Oken, Emily
Sagiv, Sharon K.
Fleisch, Abby F.
Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)
title Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)
title_full Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)
title_fullStr Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)
title_full_unstemmed Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)
title_short Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States)
title_sort per- and polyfluoroalkyl substance plasma concentrations and bone mineral density in midchildhood: a cross-sectional study (project viva, united states)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792359/
https://www.ncbi.nlm.nih.gov/pubmed/31433236
http://dx.doi.org/10.1289/EHP4918
work_keys_str_mv AT cluettrachel perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT seshasayeeshravanthim perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT rokofflisab perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT rifasshimansheryll perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT yexiaoyun perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT calafatantoniam perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT golddianer perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT coullbrent perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT gordoncatherinem perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT rosencliffordj perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT okenemily perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT sagivsharonk perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates
AT fleischabbyf perandpolyfluoroalkylsubstanceplasmaconcentrationsandbonemineraldensityinmidchildhoodacrosssectionalstudyprojectvivaunitedstates