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Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic

BACKGROUND: A few studies suggest that air pollution may decrease fertility, but prospective studies and examinations of windows of susceptibility remain unclear. OBJECTIVE: We aimed to examine the association between time-varying exposure to nitrogen dioxide ([Formula: see text]), ozone ([Formula:...

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Autores principales: Gaskins, Audrey J., Fong, Kelvin C., Abu Awad, Yara, Di, Qian, Mínguez-Alarcón, Lidia, Chavarro, Jorge E., Ford, Jennifer B., Coull, Brent A., Schwartz, Joel, Kloog, Itai, Souter, Irene, Hauser, Russ, Laden, Francine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792363/
https://www.ncbi.nlm.nih.gov/pubmed/31268361
http://dx.doi.org/10.1289/EHP4601
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author Gaskins, Audrey J.
Fong, Kelvin C.
Abu Awad, Yara
Di, Qian
Mínguez-Alarcón, Lidia
Chavarro, Jorge E.
Ford, Jennifer B.
Coull, Brent A.
Schwartz, Joel
Kloog, Itai
Souter, Irene
Hauser, Russ
Laden, Francine
author_facet Gaskins, Audrey J.
Fong, Kelvin C.
Abu Awad, Yara
Di, Qian
Mínguez-Alarcón, Lidia
Chavarro, Jorge E.
Ford, Jennifer B.
Coull, Brent A.
Schwartz, Joel
Kloog, Itai
Souter, Irene
Hauser, Russ
Laden, Francine
author_sort Gaskins, Audrey J.
collection PubMed
description BACKGROUND: A few studies suggest that air pollution may decrease fertility, but prospective studies and examinations of windows of susceptibility remain unclear. OBJECTIVE: We aimed to examine the association between time-varying exposure to nitrogen dioxide ([Formula: see text]), ozone ([Formula: see text]), fine particulate matter [Formula: see text] ([Formula: see text]), and black carbon (BC) on in vitro fertilization (IVF) outcomes. METHODS: We included 345 women (522 IVF cycles) for the [Formula: see text] , [Formula: see text] , and [Formula: see text] analyses and 339 women (512 IVF cycles) for the BC analysis enrolled in a prospective cohort at a Boston fertility center (2004–2015). We used validated spatiotemporal models to estimate daily residential exposure to [Formula: see text] , [Formula: see text] , [Formula: see text] , and BC. Multivariable discrete time Cox proportional hazards models with four periods [ovarian stimulation (OS), oocyte retrieval to embryo transfer (ET), ET to implantation, implantation to live birth] estimated odds ratios (OR) and 95% confidence intervals (CI) of failing at IVF. Time-dependent interactions were used to identify vulnerable periods. RESULTS: An interquartile range (IQR) increase in [Formula: see text] , [Formula: see text] , and BC throughout the IVF cycle was associated with an elevated odds of failing at IVF prior to live birth ([Formula: see text] , 95% CI: 0.95, 1.23 for [Formula: see text]; [Formula: see text] , 95% CI: 0.88, 1.28 for [Formula: see text]; and [Formula: see text] , 95% CI: 0.96, 1.41 for BC). This relationship significantly varied across the IVF cycle such that the association with higher exposure to air pollution during OS was strongest for early IVF failures. An IQR increase in [Formula: see text] , [Formula: see text] , and BC exposure during OS was associated with 1.42 (95% CI: 1.20, 1.69), 1.26 (95% CI: 0.96, 1.67), and 1.23 (95% CI: 0.96, 1.59) times the odds of failing prior to oocyte retrieval, and 1.32 (95% CI: 1.13, 1.54), 1.27 (95% CI: 0.98, 1.65), and 1.32 (95% CI: 1.10, 1.59) times the odds of failing prior to ET. CONCLUSION: Increased exposure to traffic-related pollutants was associated with higher odds of early IVF failure. https://doi.org/10.1289/EHP4601
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spelling pubmed-67923632019-11-06 Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic Gaskins, Audrey J. Fong, Kelvin C. Abu Awad, Yara Di, Qian Mínguez-Alarcón, Lidia Chavarro, Jorge E. Ford, Jennifer B. Coull, Brent A. Schwartz, Joel Kloog, Itai Souter, Irene Hauser, Russ Laden, Francine Environ Health Perspect Research BACKGROUND: A few studies suggest that air pollution may decrease fertility, but prospective studies and examinations of windows of susceptibility remain unclear. OBJECTIVE: We aimed to examine the association between time-varying exposure to nitrogen dioxide ([Formula: see text]), ozone ([Formula: see text]), fine particulate matter [Formula: see text] ([Formula: see text]), and black carbon (BC) on in vitro fertilization (IVF) outcomes. METHODS: We included 345 women (522 IVF cycles) for the [Formula: see text] , [Formula: see text] , and [Formula: see text] analyses and 339 women (512 IVF cycles) for the BC analysis enrolled in a prospective cohort at a Boston fertility center (2004–2015). We used validated spatiotemporal models to estimate daily residential exposure to [Formula: see text] , [Formula: see text] , [Formula: see text] , and BC. Multivariable discrete time Cox proportional hazards models with four periods [ovarian stimulation (OS), oocyte retrieval to embryo transfer (ET), ET to implantation, implantation to live birth] estimated odds ratios (OR) and 95% confidence intervals (CI) of failing at IVF. Time-dependent interactions were used to identify vulnerable periods. RESULTS: An interquartile range (IQR) increase in [Formula: see text] , [Formula: see text] , and BC throughout the IVF cycle was associated with an elevated odds of failing at IVF prior to live birth ([Formula: see text] , 95% CI: 0.95, 1.23 for [Formula: see text]; [Formula: see text] , 95% CI: 0.88, 1.28 for [Formula: see text]; and [Formula: see text] , 95% CI: 0.96, 1.41 for BC). This relationship significantly varied across the IVF cycle such that the association with higher exposure to air pollution during OS was strongest for early IVF failures. An IQR increase in [Formula: see text] , [Formula: see text] , and BC exposure during OS was associated with 1.42 (95% CI: 1.20, 1.69), 1.26 (95% CI: 0.96, 1.67), and 1.23 (95% CI: 0.96, 1.59) times the odds of failing prior to oocyte retrieval, and 1.32 (95% CI: 1.13, 1.54), 1.27 (95% CI: 0.98, 1.65), and 1.32 (95% CI: 1.10, 1.59) times the odds of failing prior to ET. CONCLUSION: Increased exposure to traffic-related pollutants was associated with higher odds of early IVF failure. https://doi.org/10.1289/EHP4601 Environmental Health Perspectives 2019-07-03 /pmc/articles/PMC6792363/ /pubmed/31268361 http://dx.doi.org/10.1289/EHP4601 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Gaskins, Audrey J.
Fong, Kelvin C.
Abu Awad, Yara
Di, Qian
Mínguez-Alarcón, Lidia
Chavarro, Jorge E.
Ford, Jennifer B.
Coull, Brent A.
Schwartz, Joel
Kloog, Itai
Souter, Irene
Hauser, Russ
Laden, Francine
Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic
title Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic
title_full Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic
title_fullStr Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic
title_full_unstemmed Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic
title_short Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic
title_sort time-varying exposure to air pollution and outcomes of in vitro fertilization among couples from a fertility clinic
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792363/
https://www.ncbi.nlm.nih.gov/pubmed/31268361
http://dx.doi.org/10.1289/EHP4601
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