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The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects
Although previous evidence has suggested that there is a genetic link between schizophrenia and creativity, the specific genetic variants that underlie the link are still largely unknown. To further explore the potential genetic link between schizophrenia and creativity, in a sample of 580 healthy H...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792478/ https://www.ncbi.nlm.nih.gov/pubmed/31649580 http://dx.doi.org/10.3389/fpsyg.2019.02218 |
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author | Wang, Dan Guo, Tingting Guo, Qi Zhang, Shun Zhang, Jinghuan Luo, Jing |
author_facet | Wang, Dan Guo, Tingting Guo, Qi Zhang, Shun Zhang, Jinghuan Luo, Jing |
author_sort | Wang, Dan |
collection | PubMed |
description | Although previous evidence has suggested that there is a genetic link between schizophrenia and creativity, the specific genetic variants that underlie the link are still largely unknown. To further explore the potential genetic link between schizophrenia and creativity, in a sample of 580 healthy Han Chinese subjects, this study aimed to (1) validate the role of Neuregulin 1 (NRG1) rs6994992 (one schizophrenia risk variant that has been previously linked to creativity in the European population) in the relationship between schizophrenia and creativity and (2) explore the associations between 10 other schizophrenia risk variants and creativity. For NRG1 rs6994992, the result validated its association with creativity measures. However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity. For other schizophrenia risk variants, the result only demonstrated a nominal association between ZNF536 rs2053079 and creativity measures which would not survive correction for multiple testing. No association between polygenic risk score for these 10 schizophrenia risk variants and creativity measures was observed. In conclusion, this study provides limited evidence for the associations between these schizophrenia risk variants and creativity in healthy Han Chinese subjects. Future studies are warranted to better understand the potential genetic link between schizophrenia and creativity. |
format | Online Article Text |
id | pubmed-6792478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67924782019-10-24 The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects Wang, Dan Guo, Tingting Guo, Qi Zhang, Shun Zhang, Jinghuan Luo, Jing Front Psychol Psychology Although previous evidence has suggested that there is a genetic link between schizophrenia and creativity, the specific genetic variants that underlie the link are still largely unknown. To further explore the potential genetic link between schizophrenia and creativity, in a sample of 580 healthy Han Chinese subjects, this study aimed to (1) validate the role of Neuregulin 1 (NRG1) rs6994992 (one schizophrenia risk variant that has been previously linked to creativity in the European population) in the relationship between schizophrenia and creativity and (2) explore the associations between 10 other schizophrenia risk variants and creativity. For NRG1 rs6994992, the result validated its association with creativity measures. However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity. For other schizophrenia risk variants, the result only demonstrated a nominal association between ZNF536 rs2053079 and creativity measures which would not survive correction for multiple testing. No association between polygenic risk score for these 10 schizophrenia risk variants and creativity measures was observed. In conclusion, this study provides limited evidence for the associations between these schizophrenia risk variants and creativity in healthy Han Chinese subjects. Future studies are warranted to better understand the potential genetic link between schizophrenia and creativity. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6792478/ /pubmed/31649580 http://dx.doi.org/10.3389/fpsyg.2019.02218 Text en Copyright © 2019 Wang, Guo, Guo, Zhang, Zhang, Luo and GeseDNA Research Team. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Wang, Dan Guo, Tingting Guo, Qi Zhang, Shun Zhang, Jinghuan Luo, Jing The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects |
title | The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects |
title_full | The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects |
title_fullStr | The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects |
title_full_unstemmed | The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects |
title_short | The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects |
title_sort | association between schizophrenia risk variants and creativity in healthy han chinese subjects |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792478/ https://www.ncbi.nlm.nih.gov/pubmed/31649580 http://dx.doi.org/10.3389/fpsyg.2019.02218 |
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