The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma

Human papilloma virus (HPV) has been implicated in the development of oropharyngeal squamous cell carcinoma (OPSCC) and is directly attributed to its increasing incidence. The immune microenvironment surrounding HPV‐associated OPSCC tumors is complex and plays a critical role in the carcinogenic pro...

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Autores principales: Subbarayan, Rahul Sridhar, Arnold, Levi, Gomez, Juan Pineda, Thomas, Sufi Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Head and Neck, and Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793605/
https://www.ncbi.nlm.nih.gov/pubmed/31637294
http://dx.doi.org/10.1002/lio2.300
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author Subbarayan, Rahul Sridhar
Arnold, Levi
Gomez, Juan Pineda
Thomas, Sufi Mary
author_facet Subbarayan, Rahul Sridhar
Arnold, Levi
Gomez, Juan Pineda
Thomas, Sufi Mary
author_sort Subbarayan, Rahul Sridhar
collection PubMed
description Human papilloma virus (HPV) has been implicated in the development of oropharyngeal squamous cell carcinoma (OPSCC) and is directly attributed to its increasing incidence. The immune microenvironment surrounding HPV‐associated OPSCC tumors is complex and plays a critical role in the carcinogenic process. The neoplastic mechanism includes cells of the innate immunity such as macrophages, and dendritic cells as well as cells of the adaptive immune process such as CD8+ T‐cells. The intricate interactions between these two arms of the immune system allow for a pro‐inflammatory and pro‐tumorigenic environment. Intensive efforts are underway to gain a greater understanding of the mechanisms involved in the immune system's role in tumor development. This study seeks to summarize the current knowledge pertaining to role of the innate and adaptive immune response in HPV‐associated OPSCC. LEVEL OF EVIDENCE: 3a
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spelling pubmed-67936052019-10-21 The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma Subbarayan, Rahul Sridhar Arnold, Levi Gomez, Juan Pineda Thomas, Sufi Mary Laryngoscope Investig Otolaryngol Head and Neck, and Tumor Biology Human papilloma virus (HPV) has been implicated in the development of oropharyngeal squamous cell carcinoma (OPSCC) and is directly attributed to its increasing incidence. The immune microenvironment surrounding HPV‐associated OPSCC tumors is complex and plays a critical role in the carcinogenic process. The neoplastic mechanism includes cells of the innate immunity such as macrophages, and dendritic cells as well as cells of the adaptive immune process such as CD8+ T‐cells. The intricate interactions between these two arms of the immune system allow for a pro‐inflammatory and pro‐tumorigenic environment. Intensive efforts are underway to gain a greater understanding of the mechanisms involved in the immune system's role in tumor development. This study seeks to summarize the current knowledge pertaining to role of the innate and adaptive immune response in HPV‐associated OPSCC. LEVEL OF EVIDENCE: 3a John Wiley & Sons, Inc. 2019-08-12 /pmc/articles/PMC6793605/ /pubmed/31637294 http://dx.doi.org/10.1002/lio2.300 Text en © 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Head and Neck, and Tumor Biology
Subbarayan, Rahul Sridhar
Arnold, Levi
Gomez, Juan Pineda
Thomas, Sufi Mary
The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma
title The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma
title_full The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma
title_fullStr The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma
title_full_unstemmed The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma
title_short The role of the innate and adaptive immune response in HPV‐associated oropharyngeal squamous cell carcinoma
title_sort role of the innate and adaptive immune response in hpv‐associated oropharyngeal squamous cell carcinoma
topic Head and Neck, and Tumor Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793605/
https://www.ncbi.nlm.nih.gov/pubmed/31637294
http://dx.doi.org/10.1002/lio2.300
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