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Prepontine non-giant neurons drive flexible escape behavior in zebrafish
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remain...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793939/ https://www.ncbi.nlm.nih.gov/pubmed/31613896 http://dx.doi.org/10.1371/journal.pbio.3000480 |
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author | Marquart, Gregory D. Tabor, Kathryn M. Bergeron, Sadie A. Briggman, Kevin L. Burgess, Harold A. |
author_facet | Marquart, Gregory D. Tabor, Kathryn M. Bergeron, Sadie A. Briggman, Kevin L. Burgess, Harold A. |
author_sort | Marquart, Gregory D. |
collection | PubMed |
description | Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system. |
format | Online Article Text |
id | pubmed-6793939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67939392019-10-25 Prepontine non-giant neurons drive flexible escape behavior in zebrafish Marquart, Gregory D. Tabor, Kathryn M. Bergeron, Sadie A. Briggman, Kevin L. Burgess, Harold A. PLoS Biol Research Article Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system. Public Library of Science 2019-10-15 /pmc/articles/PMC6793939/ /pubmed/31613896 http://dx.doi.org/10.1371/journal.pbio.3000480 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Marquart, Gregory D. Tabor, Kathryn M. Bergeron, Sadie A. Briggman, Kevin L. Burgess, Harold A. Prepontine non-giant neurons drive flexible escape behavior in zebrafish |
title | Prepontine non-giant neurons drive flexible escape behavior in zebrafish |
title_full | Prepontine non-giant neurons drive flexible escape behavior in zebrafish |
title_fullStr | Prepontine non-giant neurons drive flexible escape behavior in zebrafish |
title_full_unstemmed | Prepontine non-giant neurons drive flexible escape behavior in zebrafish |
title_short | Prepontine non-giant neurons drive flexible escape behavior in zebrafish |
title_sort | prepontine non-giant neurons drive flexible escape behavior in zebrafish |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793939/ https://www.ncbi.nlm.nih.gov/pubmed/31613896 http://dx.doi.org/10.1371/journal.pbio.3000480 |
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