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Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making

Prior expectations of movement instructions can promote preliminary action planning and influence choices. We investigated how action priors affect action-goal encoding in premotor and parietal cortices and if they bias subsequent free choice. Monkeys planned reaches according to visual cues that in...

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Detalles Bibliográficos
Autores principales: Suriya-Arunroj, Lalitta, Gail, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794075/
https://www.ncbi.nlm.nih.gov/pubmed/31612855
http://dx.doi.org/10.7554/eLife.47581
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author Suriya-Arunroj, Lalitta
Gail, Alexander
author_facet Suriya-Arunroj, Lalitta
Gail, Alexander
author_sort Suriya-Arunroj, Lalitta
collection PubMed
description Prior expectations of movement instructions can promote preliminary action planning and influence choices. We investigated how action priors affect action-goal encoding in premotor and parietal cortices and if they bias subsequent free choice. Monkeys planned reaches according to visual cues that indicated relative probabilities of two possible goals. On instructed trials, the reach goal was determined by a secondary cue respecting these probabilities. On rarely interspersed free-choice trials without instruction, both goals offered equal reward. Action priors induced graded free-choice biases and graded frontoparietal motor-goal activity, complementarily in two subclasses of neurons. Down-regulating neurons co-encoded both possible goals and decreased opposite-to-preferred responses with decreasing prior, possibly supporting a process of choice by elimination. Up-regulating neurons showed increased preferred-direction responses with increasing prior, likely supporting a process of computing net likelihood. Action-selection signals emerged earliest in down-regulating neurons of premotor cortex, arguing for an initiation of selection in the frontal lobe.
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spelling pubmed-67940752019-10-16 Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making Suriya-Arunroj, Lalitta Gail, Alexander eLife Neuroscience Prior expectations of movement instructions can promote preliminary action planning and influence choices. We investigated how action priors affect action-goal encoding in premotor and parietal cortices and if they bias subsequent free choice. Monkeys planned reaches according to visual cues that indicated relative probabilities of two possible goals. On instructed trials, the reach goal was determined by a secondary cue respecting these probabilities. On rarely interspersed free-choice trials without instruction, both goals offered equal reward. Action priors induced graded free-choice biases and graded frontoparietal motor-goal activity, complementarily in two subclasses of neurons. Down-regulating neurons co-encoded both possible goals and decreased opposite-to-preferred responses with decreasing prior, possibly supporting a process of choice by elimination. Up-regulating neurons showed increased preferred-direction responses with increasing prior, likely supporting a process of computing net likelihood. Action-selection signals emerged earliest in down-regulating neurons of premotor cortex, arguing for an initiation of selection in the frontal lobe. eLife Sciences Publications, Ltd 2019-10-15 /pmc/articles/PMC6794075/ /pubmed/31612855 http://dx.doi.org/10.7554/eLife.47581 Text en © 2019, Suriya-Arunroj and Gail http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Suriya-Arunroj, Lalitta
Gail, Alexander
Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
title Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
title_full Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
title_fullStr Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
title_full_unstemmed Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
title_short Complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
title_sort complementary encoding of priors in monkey frontoparietal network supports a dual process of decision-making
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794075/
https://www.ncbi.nlm.nih.gov/pubmed/31612855
http://dx.doi.org/10.7554/eLife.47581
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