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The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection

Background  Guidelines recommend frequent follow-up after acute aortic dissection (AAD), but optimal rates of follow-up are not clear. Methods  We examined rates of imaging and clinic visits in 267 individuals surviving AAD during recommended intervals (≤1, > 1–3, > 3–6, > 6–12 months, then...

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Autores principales: Chaddha, Ashish, Eagle, Kim A., Patel, Himanshu J., Deeb, G. Michael, Yang, Bo, Harris, Kevin M., Braverman, Alan C., Hutchison, Stuart, Evangelista, Arturo, Fattori, Rossella, Froehlich, James B., Nienaber, Christoph A., Isselbacher, Eric M., Montgomery, Dan G., Kline-Rogers, Eva, Woznicki, Elise, LaBounty, Troy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794145/
https://www.ncbi.nlm.nih.gov/pubmed/31614376
http://dx.doi.org/10.1055/s-0039-1692187
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author Chaddha, Ashish
Eagle, Kim A.
Patel, Himanshu J.
Deeb, G. Michael
Yang, Bo
Harris, Kevin M.
Braverman, Alan C.
Hutchison, Stuart
Evangelista, Arturo
Fattori, Rossella
Froehlich, James B.
Nienaber, Christoph A.
Isselbacher, Eric M.
Montgomery, Dan G.
Kline-Rogers, Eva
Woznicki, Elise
LaBounty, Troy M.
author_facet Chaddha, Ashish
Eagle, Kim A.
Patel, Himanshu J.
Deeb, G. Michael
Yang, Bo
Harris, Kevin M.
Braverman, Alan C.
Hutchison, Stuart
Evangelista, Arturo
Fattori, Rossella
Froehlich, James B.
Nienaber, Christoph A.
Isselbacher, Eric M.
Montgomery, Dan G.
Kline-Rogers, Eva
Woznicki, Elise
LaBounty, Troy M.
author_sort Chaddha, Ashish
collection PubMed
description Background  Guidelines recommend frequent follow-up after acute aortic dissection (AAD), but optimal rates of follow-up are not clear. Methods  We examined rates of imaging and clinic visits in 267 individuals surviving AAD during recommended intervals (≤1, > 1–3, > 3–6, > 6–12 months, then annually), frequency of adverse imaging findings, and the relationship between follow-up and mortality. Results  Type A and B AAD were noted in 46 and 54% of patients, respectively. Mean follow-up was 54.7 ± 13.3 months, with 52 deaths. Adverse imaging findings peaked at 6 to 12 months (5.6%), but rarely resulted in an intervention (3.4% peak at 6–12 months). Compared with those with less frequent imaging, patients with imaging for 33 to 66% of intervals ( p  = 0.22) or ≥66% of intervals ( p  = 0.77) had similar adjusted survival. In comparison to patients with fewer clinic visits, those with visits in 33 to 66% of intervals experienced lower adjusted mortality (hazards ratio: 0.47, 95% confidence interval: 0.23–0.97, p  = 0.04), with no difference seen in those with ≥66% (vs. < 33%) interval visits ( p  = 0.47). Imaging at 6 to 12 months (vs. none) was associated with decreased adjusted mortality (hazards ratio: 0.50, 95% confidence interval: 0.27–0.91, p  = 0.02), while imaging during other intervals, or clinic visits during any specific intervals, was not associated with a difference in mortality ( p  > 0.05 for each). Conclusions  Adverse imaging findings following AAD are common, but rarely require prompt intervention. Patients with the lowest and highest rates of clinic visits experienced increased mortality. While the overall rate of surveillance imaging did not correlate with mortality, adverse imaging findings and related interventions peaked at 6 to 12 months after AAD, and imaging during this time was associated with improved survival.
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spelling pubmed-67941452019-10-16 The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection Chaddha, Ashish Eagle, Kim A. Patel, Himanshu J. Deeb, G. Michael Yang, Bo Harris, Kevin M. Braverman, Alan C. Hutchison, Stuart Evangelista, Arturo Fattori, Rossella Froehlich, James B. Nienaber, Christoph A. Isselbacher, Eric M. Montgomery, Dan G. Kline-Rogers, Eva Woznicki, Elise LaBounty, Troy M. Aorta (Stamford) Background  Guidelines recommend frequent follow-up after acute aortic dissection (AAD), but optimal rates of follow-up are not clear. Methods  We examined rates of imaging and clinic visits in 267 individuals surviving AAD during recommended intervals (≤1, > 1–3, > 3–6, > 6–12 months, then annually), frequency of adverse imaging findings, and the relationship between follow-up and mortality. Results  Type A and B AAD were noted in 46 and 54% of patients, respectively. Mean follow-up was 54.7 ± 13.3 months, with 52 deaths. Adverse imaging findings peaked at 6 to 12 months (5.6%), but rarely resulted in an intervention (3.4% peak at 6–12 months). Compared with those with less frequent imaging, patients with imaging for 33 to 66% of intervals ( p  = 0.22) or ≥66% of intervals ( p  = 0.77) had similar adjusted survival. In comparison to patients with fewer clinic visits, those with visits in 33 to 66% of intervals experienced lower adjusted mortality (hazards ratio: 0.47, 95% confidence interval: 0.23–0.97, p  = 0.04), with no difference seen in those with ≥66% (vs. < 33%) interval visits ( p  = 0.47). Imaging at 6 to 12 months (vs. none) was associated with decreased adjusted mortality (hazards ratio: 0.50, 95% confidence interval: 0.27–0.91, p  = 0.02), while imaging during other intervals, or clinic visits during any specific intervals, was not associated with a difference in mortality ( p  > 0.05 for each). Conclusions  Adverse imaging findings following AAD are common, but rarely require prompt intervention. Patients with the lowest and highest rates of clinic visits experienced increased mortality. While the overall rate of surveillance imaging did not correlate with mortality, adverse imaging findings and related interventions peaked at 6 to 12 months after AAD, and imaging during this time was associated with improved survival. Thieme Medical Publishers 2019-10-15 /pmc/articles/PMC6794145/ /pubmed/31614376 http://dx.doi.org/10.1055/s-0039-1692187 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chaddha, Ashish
Eagle, Kim A.
Patel, Himanshu J.
Deeb, G. Michael
Yang, Bo
Harris, Kevin M.
Braverman, Alan C.
Hutchison, Stuart
Evangelista, Arturo
Fattori, Rossella
Froehlich, James B.
Nienaber, Christoph A.
Isselbacher, Eric M.
Montgomery, Dan G.
Kline-Rogers, Eva
Woznicki, Elise
LaBounty, Troy M.
The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
title The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
title_full The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
title_fullStr The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
title_full_unstemmed The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
title_short The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
title_sort clinical impact of imaging surveillance and clinic visit frequency after acute aortic dissection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794145/
https://www.ncbi.nlm.nih.gov/pubmed/31614376
http://dx.doi.org/10.1055/s-0039-1692187
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