Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance

Mycobacterium abscessus subspecies abscessus is major subspecies in the M. abscessus complex and is usually refractory to standard antibiotherapy. Genetic tracing of erm(41) T28 is a mechanism for monitoring macrolide resistance. We treated a patient with a pulmonary infection caused by M. abscessus...

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Autores principales: Yamaba, Yusuke, Takakuwa, Osamu, Saito, Manami, Kawae, Daisuke, Yoshihara, Misuzu, Mori, Yuta, Kunii, Eiji, Ito, Yutaka, Yoshida, Shiomi, Akita, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794162/
https://www.ncbi.nlm.nih.gov/pubmed/31178483
http://dx.doi.org/10.2169/internalmedicine.2391-18
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author Yamaba, Yusuke
Takakuwa, Osamu
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Mori, Yuta
Kunii, Eiji
Ito, Yutaka
Yoshida, Shiomi
Akita, Kenji
author_facet Yamaba, Yusuke
Takakuwa, Osamu
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Mori, Yuta
Kunii, Eiji
Ito, Yutaka
Yoshida, Shiomi
Akita, Kenji
author_sort Yamaba, Yusuke
collection PubMed
description Mycobacterium abscessus subspecies abscessus is major subspecies in the M. abscessus complex and is usually refractory to standard antibiotherapy. Genetic tracing of erm(41) T28 is a mechanism for monitoring macrolide resistance. We treated a patient with a pulmonary infection caused by M. abscessus subsp. abscessus with the erm(41) T28 polymorphism, which was susceptible to clarithromycin, and his clinical treatment course was good. The identification of the M. abscessus complex genotype is important, but clinical confirmation of clarithromycin susceptibility is also needed to plan individual treatment strategies.
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spelling pubmed-67941622019-10-17 Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance Yamaba, Yusuke Takakuwa, Osamu Saito, Manami Kawae, Daisuke Yoshihara, Misuzu Mori, Yuta Kunii, Eiji Ito, Yutaka Yoshida, Shiomi Akita, Kenji Intern Med Case Report Mycobacterium abscessus subspecies abscessus is major subspecies in the M. abscessus complex and is usually refractory to standard antibiotherapy. Genetic tracing of erm(41) T28 is a mechanism for monitoring macrolide resistance. We treated a patient with a pulmonary infection caused by M. abscessus subsp. abscessus with the erm(41) T28 polymorphism, which was susceptible to clarithromycin, and his clinical treatment course was good. The identification of the M. abscessus complex genotype is important, but clinical confirmation of clarithromycin susceptibility is also needed to plan individual treatment strategies. The Japanese Society of Internal Medicine 2019-06-07 2019-09-15 /pmc/articles/PMC6794162/ /pubmed/31178483 http://dx.doi.org/10.2169/internalmedicine.2391-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamaba, Yusuke
Takakuwa, Osamu
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Mori, Yuta
Kunii, Eiji
Ito, Yutaka
Yoshida, Shiomi
Akita, Kenji
Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance
title Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance
title_full Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance
title_fullStr Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance
title_full_unstemmed Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance
title_short Pulmonary Mycobacterium abscessus Subspecies abscessus Disease That Showed a Discrepancy Between the Genotype and Phenotype of Clarithromycin Resistance
title_sort pulmonary mycobacterium abscessus subspecies abscessus disease that showed a discrepancy between the genotype and phenotype of clarithromycin resistance
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794162/
https://www.ncbi.nlm.nih.gov/pubmed/31178483
http://dx.doi.org/10.2169/internalmedicine.2391-18
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