Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin

A 44-year-old Japanese woman was admitted to our hospital with fatigue and an altered liver function. She had been receiving atorvastatin treatment for 10 months. Although no jaundice was seen, the patient's serum alkaline phosphatase and γ-glutamyl transpeptidase levels were markedly elevated....

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Autores principales: Kuniyoshi, Noriyuki, Miyakawa, Hiroshi, Matsumoto, Kotaro, Tsunashima, Hiromichi, Sekine, Katsunori, Tsujikawa, Takayuki, Mabuchi, Masatoshi, Doi, Shinpei, Kikuchi, Kentaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794188/
https://www.ncbi.nlm.nih.gov/pubmed/31178503
http://dx.doi.org/10.2169/internalmedicine.2708-19
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author Kuniyoshi, Noriyuki
Miyakawa, Hiroshi
Matsumoto, Kotaro
Tsunashima, Hiromichi
Sekine, Katsunori
Tsujikawa, Takayuki
Mabuchi, Masatoshi
Doi, Shinpei
Kikuchi, Kentaro
author_facet Kuniyoshi, Noriyuki
Miyakawa, Hiroshi
Matsumoto, Kotaro
Tsunashima, Hiromichi
Sekine, Katsunori
Tsujikawa, Takayuki
Mabuchi, Masatoshi
Doi, Shinpei
Kikuchi, Kentaro
author_sort Kuniyoshi, Noriyuki
collection PubMed
description A 44-year-old Japanese woman was admitted to our hospital with fatigue and an altered liver function. She had been receiving atorvastatin treatment for 10 months. Although no jaundice was seen, the patient's serum alkaline phosphatase and γ-glutamyl transpeptidase levels were markedly elevated. Based on the results of a drug-induced lymphocyte-stimulation test, her liver disease was diagnosed as atorvastatin-induced hepatic injury. Subsequently, anti-mitochondrial antibodies (AMAs) were detected in her serum; however, a liver biopsy specimen did not show the characteristic features of primary biliary cholangitis. We herein report the detection of AMAs accompanied by drug-induced hepatic injury caused by atorvastatin.
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spelling pubmed-67941882019-10-17 Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin Kuniyoshi, Noriyuki Miyakawa, Hiroshi Matsumoto, Kotaro Tsunashima, Hiromichi Sekine, Katsunori Tsujikawa, Takayuki Mabuchi, Masatoshi Doi, Shinpei Kikuchi, Kentaro Intern Med Case Report A 44-year-old Japanese woman was admitted to our hospital with fatigue and an altered liver function. She had been receiving atorvastatin treatment for 10 months. Although no jaundice was seen, the patient's serum alkaline phosphatase and γ-glutamyl transpeptidase levels were markedly elevated. Based on the results of a drug-induced lymphocyte-stimulation test, her liver disease was diagnosed as atorvastatin-induced hepatic injury. Subsequently, anti-mitochondrial antibodies (AMAs) were detected in her serum; however, a liver biopsy specimen did not show the characteristic features of primary biliary cholangitis. We herein report the detection of AMAs accompanied by drug-induced hepatic injury caused by atorvastatin. The Japanese Society of Internal Medicine 2019-06-07 2019-09-15 /pmc/articles/PMC6794188/ /pubmed/31178503 http://dx.doi.org/10.2169/internalmedicine.2708-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kuniyoshi, Noriyuki
Miyakawa, Hiroshi
Matsumoto, Kotaro
Tsunashima, Hiromichi
Sekine, Katsunori
Tsujikawa, Takayuki
Mabuchi, Masatoshi
Doi, Shinpei
Kikuchi, Kentaro
Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin
title Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin
title_full Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin
title_fullStr Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin
title_full_unstemmed Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin
title_short Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin
title_sort detection of anti-mitochondrial antibodies accompanied by drug-induced hepatic injury due to atorvastatin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794188/
https://www.ncbi.nlm.nih.gov/pubmed/31178503
http://dx.doi.org/10.2169/internalmedicine.2708-19
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