Cargando…
Hydroxyurea alters circulating monocyte subsets and dampens its inflammatory potential in sickle cell anemia patients
Sickle cell anemia (SCA) is a hemolytic disease in which vaso-occlusion is an important pathophysiological mechanism. The treatment is based on hydroxyurea (HU), which decreases leukocyte counts and increases fetal hemoglobin synthesis. Different cell types are thought to contribute to vaso-occlusio...
Autores principales: | Guarda, Caroline C., Silveira-Mattos, Paulo S. M., Yahouédéhou, Sètondji C. M. A., Santiago, Rayra P., Aleluia, Milena M., Figueiredo, Camylla V. B., Fiuza, Luciana M., Carvalho, Suellen P., Oliveira, Rodrigo M., Nascimento, Valma M. L., Luz, Nívea F., Borges, Valéria M., Andrade, Bruno B., Gonçalves, Marilda S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794261/ https://www.ncbi.nlm.nih.gov/pubmed/31616024 http://dx.doi.org/10.1038/s41598-019-51339-x |
Ejemplares similares
-
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
por: Santiago, Rayra P., et al.
Publicado: (2020) -
Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients
por: Santiago, Rayra P., et al.
Publicado: (2021) -
TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
por: Santiago, Rayra Pereira, et al.
Publicado: (2020) -
Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
por: Yahouédéhou, Sètondji Cocou Modeste Alexandre, et al.
Publicado: (2018) -
Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response
por: Yahouédéhou, Sètondji Cocou Modeste Alexandre, et al.
Publicado: (2020)