Cargando…

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Microglia represent the primary resident immune cells of the central nervous system (CNS) and modulate local immune responses. Depending on their physiological functions, microglia can be classified into pro- (M1) and anti-inflammatory (M2) phenotype. Interleukin (IL)-10 is an important modulator of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laffer, Björn, Bauer, Dirk, Wasmuth, Susanne, Busch, Martin, Jalilvand, Tida Viola, Thanos, Solon, Meyer zu Hörste, Gerd, Loser, Karin, Langmann, Thomas, Heiligenhaus, Arnd, Kasper, Maren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794388/ https://www.ncbi.nlm.nih.gov/pubmed/31649508 http://dx.doi.org/10.3389/fncel.2019.00430

Ejemplares similares

Increased Hydrostatic Pressure Promotes Primary M1 Reaction and Secondary M2 Polarization in Macrophages
por: Wang, Bo, et al.
Publicado: (2020)

The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status
por: Kasper, Maren, et al.
Publicado: (2018)

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
por: Kasper, Maren, et al.
Publicado: (2021)

Identification of Ocular Autoantigens Associated With Juvenile Idiopathic Arthritis-Associated Uveitis
por: Busch, Martin, et al.
Publicado: (2019)

Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma
por: Bauer, Dirk, et al.
Publicado: (2018)

Microglia in Retinal Degeneration
por: Rashid, Khalid, et al.
Publicado: (2019)

PReS-FINAL-2150: Antiocular antibodies in children with juvenile idiopathic arthritis-associated uveitis
por: Walscheid, K, et al.
Publicado: (2013)

Microglia and Inflammatory Responses in Diabetic Retinopathy
por: Kinuthia, Urbanus Muthai, et al.
Publicado: (2020)

PReS-FINAL-2068: S100 A8/A9 serum levels reflect disease activity in juvenile idiopathic arthritis-associated uveitis
por: Walscheid, K, et al.
Publicado: (2013)

Microglia Activation and Immunomodulatory Therapies for Retinal Degenerations
por: Rashid, Khalid, et al.
Publicado: (2018)

Systematic review on treatment of juvenile idiopathic arthritis – associated uveitis
por: Heiligenhaus, Arnd
Publicado: (2014)

Cytotoxic corpus callosum lesion and mild CSF pleocytosis during hantavirus infection: a case report
por: Straeten, Frederike A., et al.
Publicado: (2022)

Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody
por: Krawczyk, Adalbert, et al.
Publicado: (2015)

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration
por: Khan, Amir Saeed, et al.
Publicado: (2020)

IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration
por: Behnke, Verena, et al.
Publicado: (2020)

Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany
por: Heiligenhaus, Arnd, et al.
Publicado: (2020)

Novel pathomechanisms in inflammatory neuropathies
por: Schafflick, David, et al.
Publicado: (2017)

High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses
por: Heming, Michael, et al.
Publicado: (2022)

Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia
por: Aslanidis, Alexander, et al.
Publicado: (2015)

Entwicklung von Klassifikationskriterien für Uveitiden von der Standardization of Uveitis Nomenclature (SUN) Working Group
por: Heiligenhaus, Arnd, et al.
Publicado: (2021)

Authors reply to the ‘Response to “Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany”’
por: Heiligenhaus, Arnd, et al.
Publicado: (2023)

Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells
por: Mertsch, Sonja, et al.
Publicado: (2013)

Trabeculectomy or modified deep sclerectomy in juvenile uveitic glaucoma
por: Heinz, Carsten, et al.
Publicado: (2011)

A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease
por: Bauer, Dirk, et al.
Publicado: (2017)

Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease
por: Speicher, Anna M., et al.
Publicado: (2022)

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration
por: Scholz, Rebecca, et al.
Publicado: (2015)

Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
por: Roesel, Martin, et al.
Publicado: (2011)

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia
por: Zhou, Xiaolai, et al.
Publicado: (2012)

Review of teriflunomide and its potential in the treatment of multiple sclerosis
por: Warnke, Clemens, et al.
Publicado: (2009)

The majority of newly diagnosed patients with juvenile idiopathic arthritis reach an inactive disease state within the first year of specialised care: data from a German inception cohort
por: Sengler, Claudia, et al.
Publicado: (2015)

Regulation of Retinal Proteome by Topical Antiglaucomatous Eye Drops in an Inherited Glaucoma Rat Model
por: Schallenberg, Maurice, et al.
Publicado: (2012)

Crystallins Are Regulated Biomarkers for Monitoring Topical Therapy of Glaucomatous Optic Neuropathy
por: Prokosch, Verena, et al.
Publicado: (2013)

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
por: Tabel, Mona, et al.
Publicado: (2022)

Life-time expression of the proteins peroxiredoxin, beta-synuclein, PARK7/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats
por: Böhm, Michael R. R., et al.
Publicado: (2015)

Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells
por: Couch, Amalie C.M., et al.
Publicado: (2023)

Occurrence and Risk Factors for Macular Edema in Patients with Juvenile Idiopathic Arthritis-Associated Uveitis
por: Tappeiner, Christoph, et al.
Publicado: (2021)

Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling
por: Szepanowski, Fabian, et al.
Publicado: (2016)

Secondary Immunodeficiency and Risk of Infection Following Immune Therapies in Neurology
por: Szepanowski, Fabian, et al.
Publicado: (2021)

Impact of Antiinflammatory Treatment on the Onset of Uveitis in Juvenile Idiopathic Arthritis: Longitudinal Analysis From a Nationwide Pediatric Rheumatology Database
por: Tappeiner, Christoph, et al.
Publicado: (2015)

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration
por: Scholz, Rebecca, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ivjd37kql96a9qniop24dptvl2