Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report

Objective: To present a patient with anti-CV2 autoimmune encephalitis admitted for Parkinson-like symptoms and bilateral leukoencephalopathy. Case report: The patient was admitted for Parkinson-like symptoms combined with loss of taste. Serum anti-CV2 antibody was positive. Cranial magnetic resonanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xuan, Wang, Huayan, Xu, Guorong, Lin, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794459/
https://www.ncbi.nlm.nih.gov/pubmed/31649611
http://dx.doi.org/10.3389/fneur.2019.01064
_version_ 1783459298674737152
author Wu, Xuan
Wang, Huayan
Xu, Guorong
Lin, Yu
author_facet Wu, Xuan
Wang, Huayan
Xu, Guorong
Lin, Yu
author_sort Wu, Xuan
collection PubMed
description Objective: To present a patient with anti-CV2 autoimmune encephalitis admitted for Parkinson-like symptoms and bilateral leukoencephalopathy. Case report: The patient was admitted for Parkinson-like symptoms combined with loss of taste. Serum anti-CV2 antibody was positive. Cranial magnetic resonance imaging revealed bilateral leukoencephalopathy. Breast cancer was detected by positron emission tomography (PET) and ultrasound. Immunotherapy was not performed. Modified radical mastectomy revealed a pT1cN0M0 breast cancer, positive for estrogen and progesterone receptors, and HER2 negative. The resting tremors disappeared by 1 week after surgery. The modified Rankin score (mRS) was four before surgery, and decreased to one at 9 months after surgery. Conclusion: Anti-CV2 autoimmune encephalitis can present as Parkinsonism with bilateral leukoencephalopathy on MRI. PET scanning can be useful to reveal an occult cancer. Treatment of the cancer may improve the paraneoplastic neurological syndrome without the need of immunosuppressive therapy.
format Online
Article
Text
id pubmed-6794459
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-67944592019-10-24 Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report Wu, Xuan Wang, Huayan Xu, Guorong Lin, Yu Front Neurol Neurology Objective: To present a patient with anti-CV2 autoimmune encephalitis admitted for Parkinson-like symptoms and bilateral leukoencephalopathy. Case report: The patient was admitted for Parkinson-like symptoms combined with loss of taste. Serum anti-CV2 antibody was positive. Cranial magnetic resonance imaging revealed bilateral leukoencephalopathy. Breast cancer was detected by positron emission tomography (PET) and ultrasound. Immunotherapy was not performed. Modified radical mastectomy revealed a pT1cN0M0 breast cancer, positive for estrogen and progesterone receptors, and HER2 negative. The resting tremors disappeared by 1 week after surgery. The modified Rankin score (mRS) was four before surgery, and decreased to one at 9 months after surgery. Conclusion: Anti-CV2 autoimmune encephalitis can present as Parkinsonism with bilateral leukoencephalopathy on MRI. PET scanning can be useful to reveal an occult cancer. Treatment of the cancer may improve the paraneoplastic neurological syndrome without the need of immunosuppressive therapy. Frontiers Media S.A. 2019-10-09 /pmc/articles/PMC6794459/ /pubmed/31649611 http://dx.doi.org/10.3389/fneur.2019.01064 Text en Copyright © 2019 Wu, Wang, Xu and Lin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wu, Xuan
Wang, Huayan
Xu, Guorong
Lin, Yu
Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report
title Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report
title_full Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report
title_fullStr Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report
title_full_unstemmed Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report
title_short Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy—A Case Report
title_sort anti-cv2 autoimmune encephalitis with parkinson-like symptoms and bilateral leukoencephalopathy—a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794459/
https://www.ncbi.nlm.nih.gov/pubmed/31649611
http://dx.doi.org/10.3389/fneur.2019.01064
work_keys_str_mv AT wuxuan anticv2autoimmuneencephalitiswithparkinsonlikesymptomsandbilateralleukoencephalopathyacasereport
AT wanghuayan anticv2autoimmuneencephalitiswithparkinsonlikesymptomsandbilateralleukoencephalopathyacasereport
AT xuguorong anticv2autoimmuneencephalitiswithparkinsonlikesymptomsandbilateralleukoencephalopathyacasereport
AT linyu anticv2autoimmuneencephalitiswithparkinsonlikesymptomsandbilateralleukoencephalopathyacasereport

Ejemplares similares