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Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease

While very rare familial forms of proteinopathy can cause Parkinson's disease (PD), Lewy body dementia (LBD) and age-related dementias, recent in-depth studies of lipid disturbances in the majority of the common forms of these diseases instead suggest a primary pathogenesis in lipid pathways. T...

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Autores principales: Isacson, Ole, Brekk, Oeystein R., Hallett, Penelope J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794469/
https://www.ncbi.nlm.nih.gov/pubmed/31649605
http://dx.doi.org/10.3389/fneur.2019.01053
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author Isacson, Ole
Brekk, Oeystein R.
Hallett, Penelope J.
author_facet Isacson, Ole
Brekk, Oeystein R.
Hallett, Penelope J.
author_sort Isacson, Ole
collection PubMed
description While very rare familial forms of proteinopathy can cause Parkinson's disease (PD), Lewy body dementia (LBD) and age-related dementias, recent in-depth studies of lipid disturbances in the majority of the common forms of these diseases instead suggest a primary pathogenesis in lipid pathways. This review synthesizes a perspective from new data that point to an interdependence of lipids and proteinopathy. This article describes disturbed relationships in lipid homeostasis that causes neuropathology to develop over time and with age, which includes altered mechanisms of glia-neuron exchange of lipids and inflammatory signals.
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spelling pubmed-67944692019-10-24 Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease Isacson, Ole Brekk, Oeystein R. Hallett, Penelope J. Front Neurol Neurology While very rare familial forms of proteinopathy can cause Parkinson's disease (PD), Lewy body dementia (LBD) and age-related dementias, recent in-depth studies of lipid disturbances in the majority of the common forms of these diseases instead suggest a primary pathogenesis in lipid pathways. This review synthesizes a perspective from new data that point to an interdependence of lipids and proteinopathy. This article describes disturbed relationships in lipid homeostasis that causes neuropathology to develop over time and with age, which includes altered mechanisms of glia-neuron exchange of lipids and inflammatory signals. Frontiers Media S.A. 2019-10-09 /pmc/articles/PMC6794469/ /pubmed/31649605 http://dx.doi.org/10.3389/fneur.2019.01053 Text en Copyright © 2019 Isacson, Brekk and Hallett. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Isacson, Ole
Brekk, Oeystein R.
Hallett, Penelope J.
Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
title Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
title_full Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
title_fullStr Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
title_full_unstemmed Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
title_short Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
title_sort novel results and concepts emerging from lipid cell biology relevant to degenerative brain aging and disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794469/
https://www.ncbi.nlm.nih.gov/pubmed/31649605
http://dx.doi.org/10.3389/fneur.2019.01053
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