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Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa
BACKGROUND: Based on the increased pre-eclampsia and HIV antenatal incidence in South Africa, we determined the angiogenic profiles due to its mechanistic link in preeclampsia development, throughout uncomplicated pregnancies in HIV positive and negative women. OBJECTIVE: To determine the angiogenic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Makerere Medical School
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794537/ https://www.ncbi.nlm.nih.gov/pubmed/31656464 http://dx.doi.org/10.4314/ahs.v19i2.4 |
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author | Ogunlola, Muhammed Reddy, Poovendhree Sibiya, Maureen N O'Connor, Laura Borg, Dorinda Haffejee, Firoza Ghuman, Shanaz Ngxongo, Thembelihle Govender, Nalini |
author_facet | Ogunlola, Muhammed Reddy, Poovendhree Sibiya, Maureen N O'Connor, Laura Borg, Dorinda Haffejee, Firoza Ghuman, Shanaz Ngxongo, Thembelihle Govender, Nalini |
author_sort | Ogunlola, Muhammed |
collection | PubMed |
description | BACKGROUND: Based on the increased pre-eclampsia and HIV antenatal incidence in South Africa, we determined the angiogenic profiles due to its mechanistic link in preeclampsia development, throughout uncomplicated pregnancies in HIV positive and negative women. OBJECTIVE: To determine the angiogenic profiles throughout uncomplicated pregnancies in HIV positive and HIV negative women. We explored possible correlations between angiogenic serum levels and selected maternal characteristics (HIV status, gestational age, maternal factors, and pregnancy outcomes). METHOD: This study was conducted at a primary health care facility in Durban, South Africa. Forty-six pregnant women aged 18–45 years, were enrolled at 10–20, 22–30 and 32–38 weeks' gestation, respectively through convenient sampling. Serum samples were collected and quantitatively evaluated using ELISAs. Clinical and epidemiological data were analysed using STATA (version 14). A probability level of p < 0.05 was considered statistically significant. RESULTS: Of those enrolled, 28.3% were nulliparous, 82% were HIV positive and none developed pre-eclampsia. Systolic and diastolic blood pressure increased slightly throughout pregnancy. Fluctuating angiogenic and anti-angiogenic levels were demonstrated during pregnancy. CONCLUSION: This study contributes to the current angiogenic knowledge in normotensive pregnancies, and may assist as a reference range against which these factors may be compared in HIV complicated pregnancies. |
format | Online Article Text |
id | pubmed-6794537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-67945372019-10-25 Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa Ogunlola, Muhammed Reddy, Poovendhree Sibiya, Maureen N O'Connor, Laura Borg, Dorinda Haffejee, Firoza Ghuman, Shanaz Ngxongo, Thembelihle Govender, Nalini Afr Health Sci Articles BACKGROUND: Based on the increased pre-eclampsia and HIV antenatal incidence in South Africa, we determined the angiogenic profiles due to its mechanistic link in preeclampsia development, throughout uncomplicated pregnancies in HIV positive and negative women. OBJECTIVE: To determine the angiogenic profiles throughout uncomplicated pregnancies in HIV positive and HIV negative women. We explored possible correlations between angiogenic serum levels and selected maternal characteristics (HIV status, gestational age, maternal factors, and pregnancy outcomes). METHOD: This study was conducted at a primary health care facility in Durban, South Africa. Forty-six pregnant women aged 18–45 years, were enrolled at 10–20, 22–30 and 32–38 weeks' gestation, respectively through convenient sampling. Serum samples were collected and quantitatively evaluated using ELISAs. Clinical and epidemiological data were analysed using STATA (version 14). A probability level of p < 0.05 was considered statistically significant. RESULTS: Of those enrolled, 28.3% were nulliparous, 82% were HIV positive and none developed pre-eclampsia. Systolic and diastolic blood pressure increased slightly throughout pregnancy. Fluctuating angiogenic and anti-angiogenic levels were demonstrated during pregnancy. CONCLUSION: This study contributes to the current angiogenic knowledge in normotensive pregnancies, and may assist as a reference range against which these factors may be compared in HIV complicated pregnancies. Makerere Medical School 2019-06 /pmc/articles/PMC6794537/ /pubmed/31656464 http://dx.doi.org/10.4314/ahs.v19i2.4 Text en © 2019 Ogunlola et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Ogunlola, Muhammed Reddy, Poovendhree Sibiya, Maureen N O'Connor, Laura Borg, Dorinda Haffejee, Firoza Ghuman, Shanaz Ngxongo, Thembelihle Govender, Nalini Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa |
title | Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa |
title_full | Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa |
title_fullStr | Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa |
title_full_unstemmed | Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa |
title_short | Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa |
title_sort | circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in kwazulu-natal, south africa |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794537/ https://www.ncbi.nlm.nih.gov/pubmed/31656464 http://dx.doi.org/10.4314/ahs.v19i2.4 |
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