Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)

In article number https://doi.org/10.1002/advs.201901299, Chunsheng Kang and co‐workers demonstrate the collateral effect of the CRISPR‐Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR‐Cas13a system induces death in EGFRvIII‐overexpressing glioma cell...

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Autores principales: Wang, Qixue, Liu, Xing, Zhou, Junhu, Yang, Chao, Wang, Guangxiu, Tan, Yanli, Wu, Ye, Zhang, Sijing, Yi, Kaikai, Kang, Chunsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794612/
http://dx.doi.org/10.1002/advs.201970124
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author Wang, Qixue
Liu, Xing
Zhou, Junhu
Yang, Chao
Wang, Guangxiu
Tan, Yanli
Wu, Ye
Zhang, Sijing
Yi, Kaikai
Kang, Chunsheng
author_facet Wang, Qixue
Liu, Xing
Zhou, Junhu
Yang, Chao
Wang, Guangxiu
Tan, Yanli
Wu, Ye
Zhang, Sijing
Yi, Kaikai
Kang, Chunsheng
author_sort Wang, Qixue
collection PubMed
description In article number https://doi.org/10.1002/advs.201901299, Chunsheng Kang and co‐workers demonstrate the collateral effect of the CRISPR‐Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR‐Cas13a system induces death in EGFRvIII‐overexpressing glioma cells. Furthermore, CRISPR‐Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system. [Image: see text]
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spelling pubmed-67946122019-10-21 Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019) Wang, Qixue Liu, Xing Zhou, Junhu Yang, Chao Wang, Guangxiu Tan, Yanli Wu, Ye Zhang, Sijing Yi, Kaikai Kang, Chunsheng Adv Sci (Weinh) Back Cover In article number https://doi.org/10.1002/advs.201901299, Chunsheng Kang and co‐workers demonstrate the collateral effect of the CRISPR‐Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR‐Cas13a system induces death in EGFRvIII‐overexpressing glioma cells. Furthermore, CRISPR‐Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system. [Image: see text] John Wiley and Sons Inc. 2019-10-16 /pmc/articles/PMC6794612/ http://dx.doi.org/10.1002/advs.201970124 Text en © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Back Cover
Wang, Qixue
Liu, Xing
Zhou, Junhu
Yang, Chao
Wang, Guangxiu
Tan, Yanli
Wu, Ye
Zhang, Sijing
Yi, Kaikai
Kang, Chunsheng
Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
title Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
title_full Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
title_fullStr Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
title_full_unstemmed Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
title_short Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
title_sort collateral effects: the crispr‐cas13a gene‐editing system induces collateral cleavage of rna in glioma cells (adv. sci. 20/2019)
topic Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794612/
http://dx.doi.org/10.1002/advs.201970124
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