Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phloretin remain elusive. METHODS: Five HCC cells were tested in vitro for sensitivit...

Descripción completa

Detalles Bibliográficos
Autores principales: Saraswati, Sarita, Alhaider, Abdulqader, Abdelgadir, Abdelgalil Mohamed, Tanwer, Pooja, Korashy, Hesham M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794763/
https://www.ncbi.nlm.nih.gov/pubmed/31619257
http://dx.doi.org/10.1186/s12964-019-0430-7

Ejemplares similares

Ejemplares similares