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Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

BACKGROUND: New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT. RESULTS: Light microscopy images of two colon cancer cell line...

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Autores principales: Depciuch, J., Stec, M., Klebowski, B., Baran, J., Parlinska-Wojtan, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794780/
https://www.ncbi.nlm.nih.gov/pubmed/31615520
http://dx.doi.org/10.1186/s12951-019-0539-2
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author Depciuch, J.
Stec, M.
Klebowski, B.
Baran, J.
Parlinska-Wojtan, M.
author_facet Depciuch, J.
Stec, M.
Klebowski, B.
Baran, J.
Parlinska-Wojtan, M.
author_sort Depciuch, J.
collection PubMed
description BACKGROUND: New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT. RESULTS: Light microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phospholipids, lipids and protein structures caused by laser irradiation in the presence of PtAu NRs. The MTS assay showed ~ 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. The calculated photothermal conversion efficiency reached 62% and 51% for the 650 nm and 808 nm lasers, respectively. CONCLUSIONS: PtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy.
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spelling pubmed-67947802019-10-21 Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy Depciuch, J. Stec, M. Klebowski, B. Baran, J. Parlinska-Wojtan, M. J Nanobiotechnology Research BACKGROUND: New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT. RESULTS: Light microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phospholipids, lipids and protein structures caused by laser irradiation in the presence of PtAu NRs. The MTS assay showed ~ 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. The calculated photothermal conversion efficiency reached 62% and 51% for the 650 nm and 808 nm lasers, respectively. CONCLUSIONS: PtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy. BioMed Central 2019-10-15 /pmc/articles/PMC6794780/ /pubmed/31615520 http://dx.doi.org/10.1186/s12951-019-0539-2 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Depciuch, J.
Stec, M.
Klebowski, B.
Baran, J.
Parlinska-Wojtan, M.
Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
title Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
title_full Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
title_fullStr Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
title_full_unstemmed Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
title_short Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
title_sort platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794780/
https://www.ncbi.nlm.nih.gov/pubmed/31615520
http://dx.doi.org/10.1186/s12951-019-0539-2
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