Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder, which causes dysfunction/loss of lower motor neurons and muscle weakness as well as atrophy. While SMA is primarily considered as a motor neuron disease, recent data suggests that survival motor neuron (SMN) deficiency in muscle c...

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Detalles Bibliográficos
Autores principales: Rehorst, Wiebke A., Thelen, Maximilian P., Nolte, Hendrik, Türk, Clara, Cirak, Sebahattin, Peterson, Jonathan M., Wong, G. William, Wirth, Brunhilde, Krüger, Marcus, Winter, Dominic, Kye, Min Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794869/
https://www.ncbi.nlm.nih.gov/pubmed/31615574
http://dx.doi.org/10.1186/s40478-019-0806-3

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