The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy

BACKGROUND: Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. CASE PRESENTATION: We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib...

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Detalles Bibliográficos
Autores principales: Mascarella, Marco A., Schweitzer, Lorne, Alreefi, Mahmoud, Silver, Jennifer, Caglar, Derin, Loo, Vivian G., Richardson, Keith, Dufresne, Philippe, Lee, Todd C., Sadeghi, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794875/
https://www.ncbi.nlm.nih.gov/pubmed/31619294
http://dx.doi.org/10.1186/s40463-019-0376-1
Descripción
Sumario:BACKGROUND: Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. CASE PRESENTATION: We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. CONCLUSION: Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.

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