The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy

BACKGROUND: Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. CASE PRESENTATION: We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib...

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Autores principales: Mascarella, Marco A., Schweitzer, Lorne, Alreefi, Mahmoud, Silver, Jennifer, Caglar, Derin, Loo, Vivian G., Richardson, Keith, Dufresne, Philippe, Lee, Todd C., Sadeghi, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794875/
https://www.ncbi.nlm.nih.gov/pubmed/31619294
http://dx.doi.org/10.1186/s40463-019-0376-1
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author Mascarella, Marco A.
Schweitzer, Lorne
Alreefi, Mahmoud
Silver, Jennifer
Caglar, Derin
Loo, Vivian G.
Richardson, Keith
Dufresne, Philippe
Lee, Todd C.
Sadeghi, Nader
author_facet Mascarella, Marco A.
Schweitzer, Lorne
Alreefi, Mahmoud
Silver, Jennifer
Caglar, Derin
Loo, Vivian G.
Richardson, Keith
Dufresne, Philippe
Lee, Todd C.
Sadeghi, Nader
author_sort Mascarella, Marco A.
collection PubMed
description BACKGROUND: Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. CASE PRESENTATION: We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. CONCLUSION: Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.
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spelling pubmed-67948752019-10-21 The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy Mascarella, Marco A. Schweitzer, Lorne Alreefi, Mahmoud Silver, Jennifer Caglar, Derin Loo, Vivian G. Richardson, Keith Dufresne, Philippe Lee, Todd C. Sadeghi, Nader J Otolaryngol Head Neck Surg Case Report BACKGROUND: Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. CASE PRESENTATION: We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. CONCLUSION: Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck. BioMed Central 2019-10-16 /pmc/articles/PMC6794875/ /pubmed/31619294 http://dx.doi.org/10.1186/s40463-019-0376-1 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Mascarella, Marco A.
Schweitzer, Lorne
Alreefi, Mahmoud
Silver, Jennifer
Caglar, Derin
Loo, Vivian G.
Richardson, Keith
Dufresne, Philippe
Lee, Todd C.
Sadeghi, Nader
The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
title The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
title_full The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
title_fullStr The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
title_full_unstemmed The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
title_short The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
title_sort infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794875/
https://www.ncbi.nlm.nih.gov/pubmed/31619294
http://dx.doi.org/10.1186/s40463-019-0376-1
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