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Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

BACKGROUND: In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Sophora genus used in traditional Chinese herbal medicine that exhibits a wide spec...

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Detalles Bibliográficos
Autores principales:	Zou, Yuming, Sarem, Melika, Xiang, Shengnan, Hu, Honggang, Xu, Weidong, Shastri, V. Prasad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794878/ https://www.ncbi.nlm.nih.gov/pubmed/31615459 http://dx.doi.org/10.1186/s12885-019-6199-7

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