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Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance

The immune system in tolerance maintains cell diversity without responding to self-antigens. Foxp3-expressing CD25(+)CD4(+) regulatory T cells (Tregs) inhibit T-cell activation through various molecular mechanisms. However, several key questions are still not resolved, including how Tregs control th...

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Detalles Bibliográficos
Autores principales:	Yamaguchi, Tomoyuki, Teraguchi, Shunsuke, Furusawa, Chikara, Machiyama, Hiroaki, Watanabe, Tomonobu M, Fujita, Hideaki, Sakaguchi, Shimon, Yanagida, Toshio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Featured Article of the Month
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794947/ https://www.ncbi.nlm.nih.gov/pubmed/31131864 http://dx.doi.org/10.1093/intimm/dxz043

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